| Three-dimensional modeling of a portable medical device for magnetic separation of particles from biological fluids. | |
| | |
MedLine Citation:
|
PMID: 17762081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A portable separator has been developed to quantitatively separate blood-borne magnetic spheres in potentially high-flow regimes for the human detoxification purpose. In the separator design, an array of biocompatible capillary tubing and magnetizable wires is immersed in an external magnetic field that is generated by two permanent magnets. The wires are magnetized and the high magnetic field gradient from the magnetized wires helps to collect blood-borne magnetic nano/micro-spheres from the blood flow. In this study, a 3D numerical model was created and the effect of tubing-wire configurations on the capture efficiency of the system was analyzed using COMSOL Multiphysics 3.3(R). The results showed that the configuration characterized by bi-directionally alternating wires and tubes was the best design with respect to the four starting configurations. Preliminary in vitro experiments verified the numerical predictions. The results helped us to optimize a prototype portable magnetic separator that is suitable for rapid sequestration of magnetic nano/micro-spheres from the human blood stream while accommodating necessary clinical boundary conditions. |
| | |
Authors:
|
Haitao Chen; Danny Bockenfeld; Dietmar Rempfer; Michael D Kaminski; Axel J Rosengart |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-08-15 |
Journal Detail:
|
Title: Physics in medicine and biology Volume: 52 ISSN: 0031-9155 ISO Abbreviation: Phys Med Biol Publication Date: 2007 Sep |
Date Detail:
|
Created Date: 2007-08-31 Completed Date: 2007-11-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
|
Languages: eng Pagination: 5205-18 Citation Subset: IM |
Affiliation:
|
Department of Neurology, The University of Chicago Medical Center, Chicago, IL 60637, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biocompatible Materials
/
isolation & purification* Blood Chemical Analysis* Complex Mixtures / isolation & purification* Computer Simulation Computer-Aided Design* Equipment Design Equipment Failure Analysis Hemofiltration / instrumentation*, methods Magnetics / instrumentation*, therapeutic use Miniaturization Models, Theoretical* Particle Size |
| Chemical | |
Reg. No./Substance:
|
0/Biocompatible Materials; 0/Complex Mixtures |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: List-mode-based reconstruction for respiratory motion correction in PET using non-rigid body transfo...
Next Document: Improvement of ESR dosimetry for thermal neutron beams through the addition of gadolinium.