| Three-dimensional magnetic resonance imaging of the phakic crystalline lens during accommodation. | |
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MedLine Citation:
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PMID: 21296812 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose. To quantify changes in crystalline lens curvature, thickness, equatorial diameter, surface area, and volume during accommodation using a novel two-dimensional (2-D) magnetic resonance imaging (MRI) paradigm to generate a complete three-dimensional (3-D) crystalline lens surface model. Methods. Nineteen volunteers, aged 19 to 30 years, were recruited. T(2)-weighted MRIs, optimised to show fluid-filled chambers of the eye, were acquired with a General Electric 3T HDx system, using an 8-channel RF head coil. Twenty-four oblique-axial slices of 0.8 mm thickness, with no inter-slice gaps, were acquired to visualise the crystalline lens. Three Maltese cross-type accommodative stimuli (at 0.17, 4.0 and 8.0 D) were presented randomly to the subjects in the MRI to examine lenticular changes with accommodation. MRIs were analysed using a modified version of the freeware software package mri3dX to generate a 3-D surface model. Results. During accommodation, mean crystalline lens thickness increased (F=33.39, P<0.001), whilst lens equatorial diameter (F=24.00, P<0.001) and surface radii both decreased (anterior surface: F=21.78, P<0.001; posterior surface: F=13.81, P<0.001). Over the same stimulus range, mean crystalline lens surface area decreased (F=7.04, P<0.005) with a corresponding increase in lens volume (F=6.06, P=0.005). These biometric changes represent a 1.82 % decrease and 2.30 % increase in crystalline lens surface area and volume, respectively. Conclusion. The results indicate that the capsular bag undergoes elastic deformation during accommodation, causing reduced surface area, whilst the observed volumetric changes oppose the theory that the lens is incompressible. |
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Authors:
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Amy L Sheppard; C John Evans; Krish D Singh; James S Wolffsohn; Mark C M Dunne; Leon N Davies |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-4 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Ophthalmic Research Group, Life and Health Sciences, Aston University, Birmingham, UK; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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