Document Detail

Three-dimensional in silico breast phantoms for multimodal image simulations.
MedLine Citation:
PMID:  22084047     Owner:  NLM     Status:  MEDLINE    
Anatomic simulators have provided researchers with the realistic objects needed to develop and evaluate medical imaging approaches. Today we have new insights into the cellular biology of breast tissues that is driving many new targeted diagnostic and therapeutic approaches, including molecular imaging. We report on our initial efforts to build a scalable framework for the construction of realistic 3-D in silico breast phantoms (ISBP) capable of leveraging existing knowledge and yet adaptable to fully integrate future discoveries. The ISBP frames are developed with scalable anatomical shapes and morphologic features as adapted from a rich literature on this topic. Frames are populated with tissue subtypes essential for imaging and object contrast functions are assigned. These data can be resampled to match the intrinsics scales of various imaging modalities; we explore mammography, sonography and computed tomography. Initial comparisons between simulated and clinical images demonstrate reasonable agreement and provides guidance for future development of a more realistic ISBP. An end-to-end simulation of breast images is described to demonstrate techniques for including stochastic variability and deterministic physical principles on which image formation is based.
David M Mahr; Rohit Bhargava; Michael F Insana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-09
Journal Detail:
Title:  IEEE transactions on medical imaging     Volume:  31     ISSN:  1558-254X     ISO Abbreviation:  IEEE Trans Med Imaging     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-05     Completed Date:  2012-06-25     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8310780     Medline TA:  IEEE Trans Med Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  689-97     Citation Subset:  IM    
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MeSH Terms
Breast / anatomy & histology*
Computer Simulation
Imaging, Three-Dimensional / instrumentation*,  methods
Mammography / instrumentation*,  methods
Models, Anatomic
Phantoms, Imaging*
Radiographic Image Enhancement
Tomography, X-Ray Computed / instrumentation*,  methods
Ultrasonography, Mammary / instrumentation*,  methods
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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