| Three-dimensional imaging of ventilation dynamics in asthmatics using multiecho projection acquisition with constrained reconstruction. | |
| | |
MedLine Citation:
|
PMID: 19785015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose of this work is to detect dynamic gas trapping in three dimensions during forced exhalation at isotropic high spatial resolution and high temporal resolution using hyperpolarized helium-3 MRI. Ten subjects underwent hyperpolarized helium-3 MRI and multidetector CT. MRI was performed throughout inspiration, breath-hold, and forced expiration. A multiecho three-dimensional projection acquisition was used to improve data collection efficiency and an iterative constrained reconstruction was implemented to improve signal to noise ratio (SNR) and increase robustness to motion. Two radiologists evaluated the dynamic MRI and breath-held multidetector CT data for gas and air trapping, respectively. Phantom studies showed the proposed technique significantly improved depiction of moving objects compared to view-sharing methods. Gas trapping was detected using MRI in five of the six asthmatic subjects who displayed air trapping with multidetector CT. Locations in disagreement were found to represent small to moderate regions of air trapping. The proposed technique provides whole-lung three-dimensional imaging of respiration dynamics at high spatial and temporal resolution and compares well to the current standard, multidetector CT. While multidetector CT can provide information about static regional air trapping, it is unable to depict dynamics in a setting more comparable to a spirometry maneuver and explore the longitudinal time evolution of the trapped regions. |
| | |
Authors:
|
James H Holmes; Rafael L O'Halloran; Ethan K Brodsky; Thorsten A Bley; Christopher J Francois; Julia V Velikina; Ronald L Sorkness; William W Busse; Sean B Fain |
Related Documents
:
|
10652925 - Free mra of the abdomen: postprocessing dynamic gadolinium-enhanced 3d axial mr images. 8553955 - Pelvic lesions in patients with treated cervical carcinoma: efficacy of pharmacokinetic... 15480945 - Dynamic contrast-enhanced mri using macromolecular contrast media for monitoring the re... 11000175 - Evaluation of the accuracy of gadobenate dimeglumine-enhanced mr imaging in the detecti... 21274685 - Neuroimaging in multiple sclerosis: neurotherapeutic implications. 21945795 - Correction of geometric distortion in fmri data. |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 62 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-11-30 Completed Date: 2010-02-22 Revised Date: 2011-05-18 |
Medline Journal Info:
|
Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1543-56 Citation Subset: IM |
Copyright Information:
|
(c) 2009 Wiley-Liss, Inc. |
Affiliation:
|
Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Algorithms Asthma / diagnosis*, physiopathology* Contrast Media Echo-Planar Imaging / methods* Female Helium / diagnostic use* Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Imaging, Three-Dimensional / methods* Isotopes / diagnostic use Male Middle Aged Pulmonary Gas Exchange* Reproducibility of Results Sensitivity and Specificity Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
2T32-CA09206-26/CA/NCI NIH HHS; R01 HL069116-01/HL/NHLBI NIH HHS; R01-HL069116/HL/NHLBI NIH HHS; T32 CA009206-26/CA/NCI NIH HHS; T32 CA009206-31/CA/NCI NIH HHS; T32 CA009206-32/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Isotopes; 7440-59-7/Helium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessment of the effects of cellular tissue properties on ADC measurements by numerical simulation ...
Next Document: Detection of lactate with a hadamard slice selected, selective multiple quantum coherence, chemical ...