Document Detail

Three-dimensional echocardiography: assessment of inter- and intra-operator variability and accuracy in the measurement of left ventricular cavity volume and myocardial mass.
MedLine Citation:
PMID:  10843104     Owner:  NLM     Status:  MEDLINE    
Accurate left ventricular (LV) volume and mass estimation is a strong predictor of cardiovascular morbidity and mortality. We propose that our technique of 3D echocardiography provides an accurate quantification of LV volume and mass by the reconstruction of 2D images into 3D volumes, thus avoiding the need for geometric assumptions. We compared the accuracy and variability in LV volume and mass measurement using 3D echocardiography with 2D echocardiography, using in vitro studies. Six operators measured the LV volume and mass of seven porcine hearts, using both 3D and 2D techniques. Regression analysis was used to test the accuracy of results and an ANOVA test was used to compute variability in measurement. LV volume measurement accuracy was 9.8% (3D) and 18.4% (2D); LV mass measurement accuracy was 5% (3D) and 9.2% (2D). Variability in LV volume quantification with 3D echocardiography was %SEMinter = 13.5%, %SEMintra = 11.4%, and for 2D echocardiography was %SEMinter = 21.5%, %SEMintra = 19.1%. We derived an equation to predict uncertainty in measurement of LV volume and mass using 3D echocardiography, the results of which agreed with our experimental results to within 13%. 3D echocardiography provided twice the accuracy for LV volume and mass measurement and half the variability for LV volume measurement as compared with 2D echocardiography.
S K Nadkarni; D R Boughner; M Drangova; A Fenster
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physics in medicine and biology     Volume:  45     ISSN:  0031-9155     ISO Abbreviation:  Phys Med Biol     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-10-23     Completed Date:  2000-10-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1255-73     Citation Subset:  IM    
Advanced Imaging Research Laboratories, John P Robarts Research Institute, and University of Western Ontario, London, Canada.
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MeSH Terms
Analysis of Variance
Biophysical Phenomena
Echocardiography / methods,  statistics & numerical data
Echocardiography, Three-Dimensional / methods*,  statistics & numerical data
Heart / anatomy & histology*
Heart Ventricles / anatomy & histology
Image Processing, Computer-Assisted / methods,  statistics & numerical data
Observer Variation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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