| Three-dimensional computational prediction of cerebrospinal fluid flow in the human brain. | |
| | |
MedLine Citation:
|
PMID: 21215965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A three-dimensional model of the human cerebrospinal fluid (CSF) spaces is presented. Patient-specific brain geometries were reconstructed from magnetic resonance images. The model was validated by comparing the predicted flow rates with Cine phase-contrast MRI measurements. The model predicts the complex CSF flow patterns and pressures in the ventricular system and subarachnoid space of a normal subject. The predicted maximum rostral to caudal CSF flow in the pontine cistern precedes the maximum rostral to caudal flow in the ventricles by about 10% of the cardiac cycle. This prediction is in excellent agreement with the subject-specific flow data. The computational results quantify normal intracranial dynamics and provide a basis for analyzing diseased intracranial dynamics. |
| | |
Authors:
|
Brian Sweetman; Michalis Xenos; Laura Zitella; Andreas A Linninger |
Related Documents
:
|
9739065 - Morphological, physiological and metabolic comparisons between runner-like and sheet-li... 7272265 - Cardiovascular responses during the menopausal hot flush. 10225615 - Forearm and calf blood flow in response to cortical arousal in normal male and female s... 6204135 - Cellular sodium concentration and vasoconstrictor state in hypertension. 2180335 - Diagnostic value of the indirect hemagglutination test for melioidosis in an endemic area. 2771525 - Effects of an aorticopulmonary shunt on lung fluid balance in the young lamb. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-01-07 |
Journal Detail:
|
Title: Computers in biology and medicine Volume: 41 ISSN: 1879-0534 ISO Abbreviation: Comput. Biol. Med. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-24 Completed Date: 2011-05-02 Revised Date: 2012-02-02 |
Medline Journal Info:
|
Nlm Unique ID: 1250250 Medline TA: Comput Biol Med Country: United States |
Other Details:
|
Languages: eng Pagination: 67-75 Citation Subset: IM |
Copyright Information:
|
Published by Elsevier Ltd. |
Affiliation:
|
Laboratory for Product and Process Design, Department of Chemical and Bioengineering, University of Illinois at Chicago, IL 60607-7052, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Brain / anatomy & histology, physiology* Cerebral Ventricles / anatomy & histology, physiology Cerebrospinal Fluid / physiology* Computational Biology Humans Hydrocephalus / physiopathology Imaging, Three-Dimensional / methods* Intracranial Pressure / physiology Magnetic Resonance Imaging, Cine Middle Aged Models, Biological* Reproducibility of Results Rheology / methods Subarachnoid Space / anatomy & histology, physiology |
| Grant Support | |
ID/Acronym/Agency:
|
5R21EB004956/EB/NIBIB NIH HHS; R21 EB004956-02/EB/NIBIB NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential susceptibility to environmental influences: the role of early temperament and parenting...
Next Document: Relative efficiencies of two air sampling methods and three culture conditions for the assessment of...