Document Detail

Three-dimensional alignment of the aggregated myocytes in the normal and hypertrophic murine heart.
MedLine Citation:
PMID:  19628727     Owner:  NLM     Status:  MEDLINE    
Several observations suggest that the transmission of myocardial forces is influenced in part by the spatial arrangement of the myocytes aggregated together within ventricular mass. Our aim was to assess, using diffusion tensor magnetic resonance imaging (DT-MRI), any differences in the three-dimensional arrangement of these myocytes in the normal heart compared with the hypertrophic murine myocardium. We induced ventricular hypertrophy in seven mice by infusion of angiotensin II through a subcutaneous pump, with seven other mice serving as controls. DT-MRI of explanted hearts was performed at 3.0 Tesla. We used the primary eigenvector in each voxel to determine the three-dimensional orientation of aggregated myocytes in respect to their helical angles and their transmural courses (intruding angles). Compared with controls, the hypertrophic hearts showed significant increases in myocardial mass and the outer radius of the left ventricular chamber (P < 0.05). In both groups, a significant change was noted from positive intruding angles at the base to negative angles at the ventricular apex (P < 0.01). Compared with controls, the hypertrophied hearts had significantly larger intruding angles of the aggregated myocytes, notably in the apical and basal slices (P < 0.001). In both groups, the helical angles were greatest in midventricular sections, albeit with significantly smaller angles in the mice with hypertrophied myocardium (P < 0.01). The use of DT-MRI revealed significant differences in helix and intruding angles of the myocytes in the mice with hypertrophied myocardium.
Boris Schmitt; Katsiaryna Fedarava; Jan Falkenberg; Kai Rothaus; Narendra K Bodhey; Carolin Reischauer; Sebastian Kozerke; Bernhard Schnackenburg; Dirk Westermann; Paul P Lunkenheimer; Robert H Anderson; Felix Berger; Titus Kuehne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-23
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  107     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-28     Completed Date:  2009-10-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  921-7     Citation Subset:  IM    
Unit of Cardiovascular Imaging-Department for Congenital Heart Disease and Pediatric Cardiology, German Heart Institute Berlin, Germany.
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MeSH Terms
Angiotensin II / pharmacology
Cardiomegaly / diagnosis,  pathology*,  ultrasonography
Cell Aggregation / drug effects,  physiology*
Diffusion Magnetic Resonance Imaging
Mice, Inbred C57BL
Myocytes, Cardiac / drug effects,  pathology*
Vasoconstrictor Agents / pharmacology
Reg. No./Substance:
0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II

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