Document Detail

Three-dimensional MRI Assessments of Patchy and Large Myocardial Infarction in Beating and Nonbeating Swine Hearts: Validation with Microscopy.
MedLine Citation:
PMID:  25018077     Owner:  NLM     Status:  In-Data-Review    
RATIONALE AND OBJECTIVES: To measure and validate patchy and large myocardial infarction (MI) at 3 days and 5 weeks in beating and nonbeating hearts using contrast-enhanced three-dimensional (3D) inversion-recovery gradient echo (IR-GRE) magnetic resonance imaging (MRI) and microscopy.
MATERIALS AND METHODS: Pigs (n = 28) were subjected to 1) patchy MI (group I), 2) large MI (group II), or 3) combined (patchy and large) MI (groups III and IV) using microemboli and/or 90-minute left anterior descending (LAD) occlusion and imaged at 3 days and 5 weeks after interventions. Gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA)-enhanced 3D and two-dimensional (2D) IR-GRE were performed for comparison in beating and nonbeating hearts. Macroscopic histochemical and microscopic histopathologic measurements were used for validation.
RESULTS: Three-dimensional images demonstrated hyperenhanced patchy microinfarction, large MI, hypoenhanced/hyperenhanced microvascular obstruction, and infarct resorption. Acute and chronic combined MI on 3D was underestimated compared to microscopy (bias: -1.8 ± 3.8%) but overestimated acute large infarction. In beating and nonbeating hearts, close correlations/agreements were found between 3D/2D acquisitions in all groups (beating hearts: r = 0.70-0.99; bias: group I 0.47 ± 2.0%, II 0.33 ± 1.2%, III 0.54 ± 1.5%, and IV 0.28 ± 1.0%).
CONCLUSIONS: The 3D IR-GRE underestimated the extent of acute and chronic combined MI compared to microscopic measurements. This sequence may have the potential to differentiate patchy from large MI and demonstrate MI healing after coronary interventions.
Robert Jablonowski; Mark W Wilson; Noor Joudi; Steven W Hetts; Maythem Saeed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Academic radiology     Volume:  21     ISSN:  1878-4046     ISO Abbreviation:  Acad Radiol     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-07-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1048-55     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 AUR. Published by Elsevier Inc. All rights reserved.
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