| Three different LDL apheresis columns efficiently and equally reduce lipoprotein(a) concentrations in patients with familial hypercholesterolemia and small apolipoprotein(a) particles. | |
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MedLine Citation:
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PMID: 22206792 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: High levels of lipoprotein(a) [Lp(a)] and apolipoprotein(a) [apo(a)] are associated with cardiovascular disease. In this study we determined apo(a) particle size and compared the Lp(a) reducing efficacy of three different LDL apheresis columns; DL-75, LA-15 and EC-50W in patients with familial hypercholesterolemia (FH). RESULTS: Average Lp(a) concentration was reduced by 70%, 74% and 75% (all p<0.0001) for DL-75, LA-15 and EC-50W, respectively. No significant changes in the relative proportion of the isoforms of 14 and 32K 4 domains were observed after apheresis. CONCLUSION: Three different LDL apheresis columns reduced Lp(a) efficiently with preserved ratio between apo(a) isoforms. |
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Authors:
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Anders Hovland; Santica Marcovina; Randolf Hardersen; Terje Enebakk; Tom Eirik Mollnes; Knut Tore Lappegård |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-27 |
Journal Detail:
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Title: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis Volume: - ISSN: 1473-0502 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101095653 Medline TA: Transfus Apher Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Coronary Care Unit, Division of Internal Medicine, Nordland Hospital, Bodø, Norway; Institute of Clinical Medicine, University of Tromsø, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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