Document Detail

Three contrast injection protocols for electrocardiogram-gated 64-slice computed tomographic angiography: comparing vessel density and perceived quality.
MedLine Citation:
PMID:  20861766     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare aortic, pulmonary artery (PA), and coronary artery (CA) density and examination quality using 3 different injection protocols for electrocardiogram-gated 64-detector row computed tomographic angiography. METHODS: We reviewed 30 consecutive computed tomographic angiography studies for each of 3 different contrast protocols (A, B, and C)-90 studies total-performed in patients with chest pain and low to moderate suspicion for coronary disease. All used a 20-mL timing bolus followed by 30 mL of saline. Protocol A (PrA) was composed of 50-mL contrast at 5 mL/s, 40-mL contrast/10-mL saline at 4 mL/s, and 40-mL saline at 4 mL/s. Protocol B (PrB) was composed of 50-mL contrast at 5 mL/s, 30- to 50-mL contrast at 3.5 mL/s (timing bolus-dependent), and 50-mL saline at 3.5 mL/s. Protocol C (PrC) was composed of 60-mL contrast at 5.5 mL/s, 50-mL contrast at 4.5 mL/s, and 50-mL saline at 3.5 mL/s. Density measurements were made at 20 points. Studies were graded for quality on a 4-point scale. RESULTS: Main PA density for PrA (263 Hounsfield units [HU]) was significantly lower than for PrB (335 HU) and PrC (366 HU). For PrA, PrB, and PrC, there were 10, 1, and 1 nondiagnostic PA studies, respectively; the numbers of good or very good quality studies were 10, 21, and 25. Left main CA densities for PrA (393 HU), PrB (353 HU), and PrC (356 HU) were not significantly different; likewise for aortic root densities (400, 375, and 372 HU). For the aortic root, the numbers of good or very good studies were 30, 27, and 28. Grade (G) is linearly related to average density per grade (D): G = 0.011 × D - 1.46, r = 0.96. CONCLUSIONS: Protocols B and C yielded consistently high attenuation of the aorta, PAs, and CAs with commensurate examination quality.
Michael K Atalay; Shawn Haji-Momenian; David J Grand
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of computer assisted tomography     Volume:  34     ISSN:  1532-3145     ISO Abbreviation:  J Comput Assist Tomogr     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-09-23     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703942     Medline TA:  J Comput Assist Tomogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  660-5     Citation Subset:  IM    
Department of Diagnostic Imaging, Rhode Island Hospital, Warren Alpert School of Medicine of Brown University, Providence, RI 02903, USA.
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MeSH Terms
Aortography / methods
Chest Pain / radiography
Confidence Intervals
Contrast Media / administration & dosage*
Coronary Angiography / methods*
Coronary Disease / radiography*
Injections, Intravenous / methods
Middle Aged
Pulmonary Artery / radiography
Radiographic Image Interpretation, Computer-Assisted
Retrospective Studies
Tomography, X-Ray Computed / methods*
Triiodobenzoic Acids / administration & dosage*
Reg. No./Substance:
0/Contrast Media; 0/Triiodobenzoic Acids; 92339-11-2/iodixanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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