Document Detail

Three concentrations of levobupivacaine for ilioinguinal/iliohypogastric nerve block in ambulatory pediatric surgery.
MedLine Citation:
PMID:  19833270     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To compare the postoperative analgesia of three different concentrations of levobupivacaine for ilioinguinal/iliohypogastric (II/IH) block in children undergoing inguinal hernia repair. DESIGN: Double-blind, prospective, randomized, controlled trial. SETTING: Operating room and postoperative recovery area of a university hospital. PATIENTS: 73 ASA physical status I and II children, aged one to 6 years, scheduled for outpatient inguinal hernia repair. INTERVENTIONS: Patients were randomized to receive one of three levobupivacaine concentrations: 0.125% (L0.125), 0.25% (L0.25), or 0.375% (L0.375). All patients received standard anesthesia with sevoflurane and II/IH nerve block. MEASUREMENTS: Heart rate (HR), non invasive blood pressure (NIBP), respiratory rate, end-tidal carbon dioxide concentration (ETCO(2)), and oxygen saturation via pulse oximetry (SpO(2)) were monitored during surgery. Postoperative pain scores with CHEOPS (Children's Hospital of Eastern Ontario Pain Scale) and need for rescue analgesia postoperatively were measured and recorded. MAIN RESULTS: 60 patients entered the postoperative observational period. The number of patients who received rescue analgesia was comparable in the three groups. In Group L0.125, mean CHEOPS score was significantly higher, and time to first administration of rescue analgesia was shorter, than in the other two groups (P < 0.05). Pain scores and time to first administration of rescue analgesia were comparable between Groups L0.25 and L0.375. CONCLUSIONS: II/IH nerve block using 0.4 mL kg(-1) of 0.25% levobupivacaine provided satisfactory postoperative pain relief after inguinal herniorraphy.
Nicola Disma; Pietro Tuo; Sarah Pellegrino; Marinella Astuto
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  21     ISSN:  1873-4529     ISO Abbreviation:  J Clin Anesth     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2010-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-93     Citation Subset:  IM    
Department of Anesthesia, Gaslini Children's Hospital, 16147 Genoa, Italy.
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MeSH Terms
Ambulatory Surgical Procedures / methods
Anesthetics, Inhalation / therapeutic use
Anesthetics, Local / administration & dosage,  therapeutic use*
Bupivacaine / administration & dosage,  analogs & derivatives,  therapeutic use
Child, Preschool
Dose-Response Relationship, Drug
Double-Blind Method
Hernia, Inguinal / surgery
Hospitals, University
Methyl Ethers / therapeutic use
Nerve Block / methods*
Pain Measurement
Pain, Postoperative / drug therapy*
Prospective Studies
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Local; 0/Methyl Ethers; 0/levobupivacaine; 2180-92-9/Bupivacaine; 28523-86-6/sevoflurane

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