Document Detail

Three-component coupling using arynes and aminosilanes for ortho-selective double functionalization of aromatic skeletons.
MedLine Citation:
PMID:  18570480     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Arynes were found to couple with aminosilanes and carbonyl compounds in the presence of benzoic acid to provide 2-aminobenzhydrols. Sulfonylimines could also be applied to the reaction, enabling amino and aminomethyl moieties to be incorporated into contiguous positions of aromatic skeletons. Only a small amount of the three-component coupling product was obtained in the absence of benzoic acid, which confirms its vital role in the present reaction.
Takami Morishita; Hiroyuki Fukushima; Hiroto Yoshida; Joji Ohshita; Atsutaka Kunai
Publication Detail:
Type:  Journal Article     Date:  2008-06-21
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  73     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-11     Completed Date:  2008-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5452-7     Citation Subset:  -    
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima, Japan.
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