Document Detail

Three clinical syndromes of schizophrenia in untreated subjects: relation to brain glucose activity measured by positron emission tomography (PET).
MedLine Citation:
PMID:  8297804     Owner:  NLM     Status:  MEDLINE    
A number of studies of chronically ill, medicated patients have found that the clinical symptoms of schizophrenia segregate into three syndromes which can be labelled poverty, disorganization, and reality distortion. It has been previously found that each of these syndromes is associated with a specific pattern of perfusion (rCBF) in paralimbic and association cortex and in related subcortical nuclei. We replicated the symptom factors in 20 untreated subjects. Utilizing positron emission tomography with 18-F-fluorodeoxyglucose as a tracer for glucose metabolism, we reconstructed a map of the entire cortical activity from 16 to 20 tomographic slices. Each of the three syndromes was associated with a different pattern of regional glucose metabolism. Findings in common with previous studies were an association of poverty with left cortical metabolic activity in prefrontal and superior parietal areas, reality distortion with left temporal activity, and disorganization with left inferior parietal lobule. This is the first report of an association between regional metabolic activity and clinical syndromes in untreated patients, strengthening previous models of distributed neural networks in this disorder.
R D Kaplan; H Szechtman; S Franco; B Szechtman; C Nahmias; E S Garnett; S List; J M Cleghorn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Schizophrenia research     Volume:  11     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-03-08     Completed Date:  1994-03-08     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Blood Glucose / metabolism*
Brain Mapping
Cerebral Cortex / radionuclide imaging*
Deoxyglucose / analogs & derivatives,  diagnostic use,  metabolism
Dominance, Cerebral / physiology
Fluorodeoxyglucose F18
Middle Aged
Psychiatric Status Rating Scales
Schizophrenia / radionuclide imaging*
Schizophrenic Psychology*
Tomography, Emission-Computed*
Grant Support
Reg. No./Substance:
0/Blood Glucose; 154-17-6/Deoxyglucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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