Document Detail


Three autacoids--endogenous digitalis-like factor, clonidine-displacing substance, and quinidine-like immunoreactivity.
MedLine Citation:
PMID:  8711393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The existence of endogenous ligands of opioid receptors prompted research of a potential endogenous digitalis-like factor (DLF) and of endogenous clonidine-displacing substance (CDS). Within eleven years of research, endogenous ouabaine was identified as DLF. It originates in the adrenal cortex. Its physiological role is not yet clear. Most probably, endogenous ouabaine is primarily active in regulation of natriuresis and of blood pressure. The CDS originates in the brain and is active in regulation of blood pressure as well. Its chemical formula was recently identified as agmatine. The potential presence of further autacoids like, e.g. endogenous quinidine-like substance remains to be clarified.
Authors:
F Kölbel; V Schreiber
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Sborník lékar̆ský     Volume:  96     ISSN:  0036-5327     ISO Abbreviation:  Sb Lek     Publication Date:  1995  
Date Detail:
Created Date:  1996-09-11     Completed Date:  1996-09-11     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0025770     Medline TA:  Sb Lek     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  405-15     Citation Subset:  IM    
Affiliation:
Ist Dept. of Medicine, 2nd Medical Faculty, Charles University, Prague, Czech Republic.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autacoids* / analysis,  chemistry,  physiology
Cardenolides
Clonidine / analogs & derivatives*,  analysis,  chemistry,  metabolism
Digoxin*
Enzyme Inhibitors / analysis,  chemistry,  metabolism
Humans
Quinidine / immunology*
Saponins* / analysis,  chemistry,  metabolism
Chemical
Reg. No./Substance:
0/Autacoids; 0/Cardenolides; 0/Enzyme Inhibitors; 0/Saponins; 0/digoxin-like factors; 20830-75-5/Digoxin; 4205-90-7/Clonidine; 56-54-2/Quinidine; 91432-88-1/clonidine-displacing substance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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