Document Detail

Three approaches to the development of selective bilayer amperometric biosensors for glucose by in situ electropolymerization.
MedLine Citation:
PMID:  10605893     Owner:  NLM     Status:  MEDLINE    
Three different glucose oxidase biosensors for the enzymatic determination of glucose, based on bilayer polymer coatings consisting of polypyrrole (PPy) and poly(o-phenylenediamine), were developed. The electrode substrates are Pt metal, carbon paste and an organic conducting salt (tetrathiafulvalene-tetracyanoquinodimethane), which introduces appreciable variability in the electrode construction process. The three sensors were compared with one another and with bare and PPy monolayer-coated sensors in terms of performance in the determination of glucose in a synthetic serum sample. These configurations provide improved selectivity against the interferences of electroactive species such as ascorbic acid and uric acid, frequently present in biological samples, and the differences between them can be taken advantage of in application to different kinds of samples.
J C Vidal; E García; S Méndez; P Yarnoz; J R Castillo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Analyst     Volume:  124     ISSN:  0003-2654     ISO Abbreviation:  Analyst     Publication Date:  1999 Mar 
Date Detail:
Created Date:  2000-01-11     Completed Date:  2000-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372652     Medline TA:  Analyst     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  319-24     Citation Subset:  IM    
Department of Analytical Chemistry, GEAS, Faculty of Sciences, University of Zaragoza, Spain.
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MeSH Terms
Biosensing Techniques
Blood Glucose / analysis*
Blood Substitutes
Reg. No./Substance:
0/Blood Glucose; 0/Blood Substitutes; 0/Polymers

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