| Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1. | |
| | |
MedLine Citation:
|
PMID: 21059917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Three-amino-acid-loop-extension (TALE) homeodomain proteins including Meis and Pbx families are generally recognized for their roles in growth and differentiation during vertebrate embryogenesis and tumorigenesis. Whereas genetic studies indicate that Pbx1 regulates the development and function of insulin-producing pancreatic β-cells, the role of Meis family members in β-cells is still unknown. Here we show that Meis3 is abundantly expressed in pancreatic islets and β-cells and that it regulates β-cell survival. We further identify the 3-phosphoinositide-dependent protein kinase 1 (PDK1), a well-known kinase involved in the PI3K-Akt signaling pathway, as a direct Meis3 target, which mediates its role in β-cell survival. This regulatory module appears to function broadly as we also identify Meis3 regulation of cell survival and PDK1 expression in ovarian carcinoma cells, suggesting a unique function for Meis3 beyond the traditional roles for TALE homeodomain factors during embryogenesis. |
| | |
Authors:
|
Jiangying Liu; You Wang; Morris J Birnbaum; Doris A Stoffers |
Related Documents
:
|
20803707 - Concurrently using rosiglitazone prevents glucosamine-induced islet beta-cell apoptosis... 22441427 - Biosynthesis of iminodiacetic acid from iminodiacetonitrile by immobilized recombinant ... 6500607 - Sensitivity of human pancreatic carcinoma cell line (mia paca-2) to bisantrene and thep... 10828857 - Possible relationship between changes in islet neogenesis and islet neogenesis-associat... 23683497 - Activation of p53 with nutlin-3a radiosensitizes lung cancer cells via enhancing radiat... 3116927 - Changes in escherichia coli cells starved in seawater or grown in seawater-wastewater m... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-11-08 |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: 2011-01-20 Revised Date: 2013-04-17 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
|
Languages: eng Pagination: 20494-9 Citation Subset: IM |
Affiliation:
|
Institute for Diabetes, Obesity, and Metabolism and the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apoptosis / genetics*, physiology Blotting, Western Cell Line, Tumor Cell Survival / genetics, physiology Chromatin Immunoprecipitation DNA Primers / genetics Homeodomain Proteins / genetics, metabolism* In Situ Nick-End Labeling Islets of Langerhans / metabolism* Male Mice Mice, Inbred C57BL Microarray Analysis Protein-Serine-Threonine Kinases / genetics, metabolism* RNA, Small Interfering / genetics Reverse Transcriptase Polymerase Chain Reaction Transcription Factors / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
P01 DK049210/DK/NIDDK NIH HHS; P30DK19525/DK/NIDDK NIH HHS; P30DK50306/DK/NIDDK NIH HHS; R01 DK068157/DK/NIDDK NIH HHS; R01 DK068157/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/DNA Primers; 0/Homeodomain Proteins; 0/Meis3 protein, mouse; 0/RNA, Small Interfering; 0/Transcription Factors; EC 2.7.1.-/3-phosphoinositide-dependent protein kinase; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Human tumor virus utilizes exosomes for intercellular communication.
Next Document: Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birt...