| The three "R"s of blood transfusion in 2020; routine, reliable and robust. | |
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MedLine Citation:
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PMID: 20513559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To predict the timing and nature of future changes in the practice of blood transfusion, several factors must be considered. The historical rate of change of a scientific field can often provide a rough guide to the rate of future progress. To improve the accuracy of these predictions, historical rates must be adjusted to take into account the decelerating effects of technological or methodological barriers to progress, together with the potentially accelerating effects of transformative technology breakthroughs and unmet needs in the field that act as drivers for change. The cumulative impact of unpredictable and, often, limited availability of traditional blood donors, increasingly elderly populations, the potential for storage-associated adverse events, and increasingly prevalent transfusion-transmittable diseases is likely to provide significant drive to develop transformational alternatives to current transfusion practices. Considering the current stage of development of stem cell-based therapeutics and the rates of change in clinically compatible bioreactors and cell sorting systems, it is reasonable to believe that stem cell-based ex vivo manufacture of blood components will become routine, robust, and reliable within the next decade. |
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Authors:
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Stewart Abbot |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinics in laboratory medicine Volume: 30 ISSN: 1557-9832 ISO Abbreviation: Clin. Lab. Med. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-01 Completed Date: 2010-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100174 Medline TA: Clin Lab Med Country: United States |
Other Details:
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Languages: eng Pagination: 405-17 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010. Published by Elsevier Inc. |
Affiliation:
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Celgene Cellular Therapeutics, 7 Powderhorn Drive, Warren, NJ 07059, USA. sabbot@celgene.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bioreactors Cell Culture Techniques / instrumentation, methods Cell Separation / instrumentation, methods Erythrocyte Transfusion / methods*, standards Humans Reproducibility of Results Stem Cells / cytology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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