Document Detail


Three New Phenolic Compounds from the Lichen Thamnolia vermicularis and Their Antiproliferative Effects in Prostate Cancer Cells.
MedLine Citation:
PMID:  21796577     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Three new phenolic compounds, thamnoliadepsides A ( 1), B ( 2), and thamnolic acid A ( 3), and seven known compounds, everninic acid ( 4), baeomycesic acid ( 5), β-orcinol ( 6), β-resorcylic acid ( 7), ethyl orsellinate ( 8), squamatic acid ( 9), and vermicularin ( 10), were isolated from the lichen THAMNOLIA VERMICULARIS (Sw.) Ach. ex Schaerer. Their structures were determined based on spectroscopic analysis, including 2D-NMR experiments and HR-MS techniques. Compound 1 inhibited growth of prostate cancer cells and bonded to G-quadruplex DNA based on NMR determination.
Authors:
Jia Guo; Zhan-Lin Li; Ao-Li Wang; Xiao-Qiu Liu; Jian Wang; Xin Guo; Yong-Kui Jing; Hui-Ming Hua
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Publication Detail:
Type:  LETTER     Date:  2011-7-27
Journal Detail:
Title:  Planta medica     Volume:  -     ISSN:  1439-0221     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, P. R. China.
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