| Three-dimensional multiphase time-resolved low-dose contrast-enhanced magnetic resonance angiography using TWIST on a 32-channel coil at 3 T: a quantitative and qualitative comparison of a conventional gadolinium chelate with a high-relaxivity agent. | |
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MedLine Citation:
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PMID: 20861769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate low-dose contrast-enhanced magnetic resonance angiography (CE-MRA) at high temporal and spatial resolution for imaging of abdominal vascular structures. MATERIALS AND METHODS: Contrast-enhanced magnetic resonance angiography (TWIST [time-resolved angiography with interleaved stochastic trajectories]) was performed in 8 male New Zealand white rabbits at 3 T using a prototype 32-channel coil. Gadoteridol (Gd-HP-DO3A, ProHance; Bracco Imaging SpA, Milan, Italy) and the high-relaxivity agent gadobenate dimeglumine (Gd-BOPTA, MultiHance; Bracco Imaging SpA), each at a dose of 0.04 mmol/kg body weight, were used in an intraindividual comparison. Quantitative analysis of contrast-to-noise ratio (CNR) was performed in regions of interest placed in the aorta and the adjacent tissues. The image quality in the aorta, external iliac artery, and vena cava was categorized by 2 independent blinded readers from excellent (1) to poor (3). RESULTS: A significantly (P < 0.001) higher CNR was obtained with gadobenate dimeglumine. The improved CNR led to a better delineation of the external iliac arteries. Qualitative rating showed the image quality to be excellent for gadobenate dimeglumine and adequate for gadoteridol. CONCLUSIONS: Time-resolved CE-MRA performed at 3 T with a 32-channel volume coil can be improved using the high-relaxivity agent gadobenate dimeglumine, which increases quality and quantity of vessel enhancement. |
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Authors:
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Frederik L Giesel; Val Runge; Miles Kirchin; Amit Mehndiratta; Lars Gerigk; Body Corell; Carl von Gall; Hans-Ulrich Kauczor; Marco Essig |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of computer assisted tomography Volume: 34 ISSN: 1532-3145 ISO Abbreviation: J Comput Assist Tomogr Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-09-23 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703942 Medline TA: J Comput Assist Tomogr Country: United States |
Other Details:
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Languages: eng Pagination: 678-83 Citation Subset: IM |
Affiliation:
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German Cancer Research Center, Department of Radiology, Heidelberg, Germany. f.giesel@dkfz.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Abdominal / radiography* Contrast Media / administration & dosage* Heterocyclic Compounds / administration & dosage* Iliac Artery / radiography* Image Processing, Computer-Assisted Imaging, Three-Dimensional / methods* Magnetic Resonance Angiography / methods* Male Meglumine / administration & dosage, analogs & derivatives* Organometallic Compounds / administration & dosage* Rabbits Venae Cavae / radiography* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Heterocyclic Compounds; 0/Organometallic Compounds; 112188-16-6/gadoteridol; 113662-23-0/gadobenic acid; 6284-40-8/Meglumine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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