Document Detail


Three-dimensional multiphase time-resolved low-dose contrast-enhanced magnetic resonance angiography using TWIST on a 32-channel coil at 3 T: a quantitative and qualitative comparison of a conventional gadolinium chelate with a high-relaxivity agent.
MedLine Citation:
PMID:  20861769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate low-dose contrast-enhanced magnetic resonance angiography (CE-MRA) at high temporal and spatial resolution for imaging of abdominal vascular structures.
MATERIALS AND METHODS: Contrast-enhanced magnetic resonance angiography (TWIST [time-resolved angiography with interleaved stochastic trajectories]) was performed in 8 male New Zealand white rabbits at 3 T using a prototype 32-channel coil. Gadoteridol (Gd-HP-DO3A, ProHance; Bracco Imaging SpA, Milan, Italy) and the high-relaxivity agent gadobenate dimeglumine (Gd-BOPTA, MultiHance; Bracco Imaging SpA), each at a dose of 0.04 mmol/kg body weight, were used in an intraindividual comparison. Quantitative analysis of contrast-to-noise ratio (CNR) was performed in regions of interest placed in the aorta and the adjacent tissues. The image quality in the aorta, external iliac artery, and vena cava was categorized by 2 independent blinded readers from excellent (1) to poor (3).
RESULTS: A significantly (P < 0.001) higher CNR was obtained with gadobenate dimeglumine. The improved CNR led to a better delineation of the external iliac arteries. Qualitative rating showed the image quality to be excellent for gadobenate dimeglumine and adequate for gadoteridol.
CONCLUSIONS: Time-resolved CE-MRA performed at 3 T with a 32-channel volume coil can be improved using the high-relaxivity agent gadobenate dimeglumine, which increases quality and quantity of vessel enhancement.
Authors:
Frederik L Giesel; Val Runge; Miles Kirchin; Amit Mehndiratta; Lars Gerigk; Body Corell; Carl von Gall; Hans-Ulrich Kauczor; Marco Essig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of computer assisted tomography     Volume:  34     ISSN:  1532-3145     ISO Abbreviation:  J Comput Assist Tomogr     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-09-23     Completed Date:  2010-10-19     Revised Date:  2013-01-14    
Medline Journal Info:
Nlm Unique ID:  7703942     Medline TA:  J Comput Assist Tomogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  678-83     Citation Subset:  IM    
Affiliation:
German Cancer Research Center, Department of Radiology, Heidelberg, Germany. f.giesel@dkfz.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Abdominal / radiography*
Contrast Media / administration & dosage*
Heterocyclic Compounds / administration & dosage*
Iliac Artery / radiography*
Image Processing, Computer-Assisted
Imaging, Three-Dimensional / methods*
Magnetic Resonance Angiography / methods*
Male
Meglumine / administration & dosage,  analogs & derivatives*
Organometallic Compounds / administration & dosage*
Rabbits
Venae Cavae / radiography*
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Heterocyclic Compounds; 0/Organometallic Compounds; 0199MV609F/gadoteridol; 15G12L5X8K/gadobenic acid; 6284-40-8/Meglumine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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