Document Detail


Three-dimensional hemodynamics in the human pulmonary arteries under resting and exercise conditions.
MedLine Citation:
PMID:  20640512     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biomechanical forces associated with blood flow have been shown to play a role in pulmonary vascular cell health and disease. Therefore, the quantification of human pulmonary artery hemodynamic conditions under resting and exercise states can be useful in investigating the physiology of disease development and treatment outcomes. In this study, a combined magnetic resonance imaging and computational fluid dynamics approach was used to quantify pulsatile flow fields, wall shear stress (WSS), oscillations in WSS (OSI), and energy efficiency in six subject-specific models of the human pulmonary vasculature with high spatial and temporal resolution. Averaging over all subjects, WSS was found to increase from 19.8±4.0 to 51.8±6.7 dynes/cm2, and OSI was found to decrease from 0.094±0.016 to 0.081±0.015 in the proximal pulmonary arteries between rest and exercise conditions (p<0.05). These findings demonstrate the localized, biomechanical effects of exercise. Furthermore, an average decrease of 10% in energy efficiency was noted between rest and exercise. These data indicate the amount of energy dissipation that typically occurs with exercise and may be useful in future surgical planning applications.
Authors:
Beverly T Tang; Tim A Fonte; Frandics P Chan; Philip S Tsao; Jeffrey A Feinstein; Charles A Taylor
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-07-17
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  39     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-24     Completed Date:  2011-04-11     Revised Date:  2013-08-01    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  347-58     Citation Subset:  IM    
Affiliation:
Department of Mechanical Engineering, Stanford University, Stanford, CA 94305-5431, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Flow Velocity / physiology
Blood Pressure / physiology
Computer Simulation
Humans
Imaging, Three-Dimensional
Middle Aged
Models, Anatomic
Models, Cardiovascular*
Physical Exertion / physiology*
Pulmonary Artery / anatomy & histology*,  physiology*
Rest / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
P41 RR09784/RR/NCRR NIH HHS; U54 GM0 72970/GM/NIGMS NIH HHS; U54 GM072970/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Over-the-counter sales of antibiotics from community pharmacies in Abu Dhabi.
Next Document:  Effects of central airway shunting on the mechanical impedance of the mouse lung.