| Three-dimensional hemodynamics in the human pulmonary arteries under resting and exercise conditions. | |
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MedLine Citation:
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PMID: 20640512 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The biomechanical forces associated with blood flow have been shown to play a role in pulmonary vascular cell health and disease. Therefore, the quantification of human pulmonary artery hemodynamic conditions under resting and exercise states can be useful in investigating the physiology of disease development and treatment outcomes. In this study, a combined magnetic resonance imaging and computational fluid dynamics approach was used to quantify pulsatile flow fields, wall shear stress (WSS), oscillations in WSS (OSI), and energy efficiency in six subject-specific models of the human pulmonary vasculature with high spatial and temporal resolution. Averaging over all subjects, WSS was found to increase from 19.8±4.0 to 51.8±6.7 dynes/cm2, and OSI was found to decrease from 0.094±0.016 to 0.081±0.015 in the proximal pulmonary arteries between rest and exercise conditions (p<0.05). These findings demonstrate the localized, biomechanical effects of exercise. Furthermore, an average decrease of 10% in energy efficiency was noted between rest and exercise. These data indicate the amount of energy dissipation that typically occurs with exercise and may be useful in future surgical planning applications. |
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Authors:
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Beverly T Tang; Tim A Fonte; Frandics P Chan; Philip S Tsao; Jeffrey A Feinstein; Charles A Taylor |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-07-17 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 39 ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 347-58 Citation Subset: IM |
Affiliation:
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Department of Mechanical Engineering, Stanford University, Stanford, CA 94305-5431, USA. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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P41 RR09784/RR/NCRR NIH HHS; U54 GM0 72970/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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