Document Detail


Three-Dimensional Fibroblast Cultures Stimulate Improved Ventricular Performance In Chronically Ischemic Canine Hearts.
MedLine Citation:
PMID:  21529261     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The current study's purpose was to evaluate the safety and biological effect of a scaffold-based, three-dimensional, human dermal fibroblast culture (3DFC, also known as AngineraTM) to treat chronically ischemic canine hearts. It was hypothesized that treatment with 3DFC would be safe and significantly improve ventricular performance and wall motion. In this study, chronic myocardial ischemia was induced in forty animals through the surgical placement of an ameroid constrictor. Approximately 30 days following ameroid placement animals were randomized into four test groups: 1) sham treatment, 2) one unit of acellular 3DFC, 3) one unit of viable 3DFC, or 4) three units of viable 3DFC. Animals were necropsied 30 or 90 days following treatment. Evaluation of the safety endpoint demonstrated the safety of 3DFC at all dosing levels and at both time points. Additionally, parameters of cardiac output (CO), left ventricular ejection fraction (LVEF), left ventricular end systolic volume index (LVESVI), and systolic wall thickening (SWT) support the conclusions that 3DFC stimulates a positive biologic effect on ischemic canine hearts. Furthermore, these data support the conclusion that treatment with viable 3DFC improves ventricular performance and ventricular wall motion in chronically ischemic canine hearts 30 days after treatment.
Authors:
Robert S Kellar; Stuart K Williams; Gail K Naughton; Gianine M Figliozzi; Michael Siani-Rose
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-30
Journal Detail:
Title:  Tissue engineering. Part A     Volume:  -     ISSN:  1937-335X     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101466659     Medline TA:  Tissue Eng Part A     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Development Engineering Sciences, Flagstaff, Arizona, United States; rskellar@des-company.com.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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