Document Detail

Three- and 4-dimensional ultrasonography in the prenatal evaluation of fetal anomalies associated with trisomy 18.
MedLine Citation:
PMID:  18577668     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to assess the usefulness of 3- and 4-dimensional ultrasonography (3D/4DUS) for the description of anomalies associated with trisomy 18 and to determine whether 3D/4DUS adds diagnostic information over what is provided by conventional 2-dimensional ultrasonography (2DUS) alone. METHODS: Twenty-six fetuses subsequently proven to have trisomy 18 underwent prenatal ultrasonographic evaluations by both 2DUS and 3D/4DUS. Volume data sets were acquired by the same sonographers after the conventional 2DUS examinations and were explored with 4-dimensional imaging software by another independent examiner blinded to the indications of 2DUS. The findings detected by 2DUS and 3D/4DUS were compared with those acquired at autopsy. The sensitivity of each modality for detecting anomalies was calculated and compared by the McNemar test. RESULTS: Excluding polyhydramnios, there were 131 anomalies confirmed postnatally in 26 fetuses with trisomy 18. There was a statistically significant difference in the sensitivity for detecting anomalies between 3D/4DUS and 2DUS (93.89% versus 73.28%; McNemar value = 23.31; P < .05), especially in anomalies of the face/neck (96.15% versus 65.38%; McNemar value = 6.13; P < .05) and extremities (96.3% versus 48.15%; McNemar value = 11.07; P < .05). Three- and 4-dimensional ultrasonography provided additional diagnostic information for 83.97% of the anomalies related to trisomy 18 and influenced the obstetric management of 4 fetuses. CONCLUSIONS: Three- and 4-dimensional ultrasonography offered diagnostic advantages for many anomalies associated with trisomy 18, especially for anomalies of the extremities and face. This modality could be a powerful adjunct to 2DUS in the prenatal anatomic evaluation of fetuses with trisomy 18.
Yu Zheng; Xiao-Dong Zhou; Ya-Li Zhu; Xi-Lin Wang; Yun-Qiu Qian; Xiao-Ying Lei; Bi-Liang Chen; Ming Yu; Xiao-Yan Xin
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  27     ISSN:  0278-4297     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-25     Completed Date:  2008-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1041-51     Citation Subset:  IM    
Department of Diagnostic Ultrasonography, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
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MeSH Terms
Abnormalities, Multiple / diagnosis
Chromosomes, Human, Pair 18*
Diagnosis, Differential
Fetal Diseases / diagnosis*
Imaging, Three-Dimensional / methods*
Observer Variation
Predictive Value of Tests
Reproducibility of Results
Sensitivity and Specificity
Trisomy / diagnosis*
Ultrasonography, Prenatal / methods*
Video Recording
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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