Document Detail

Three 20-minute interspaced salbutamol inhalations as a test for the diagnosis of reversible airflow limitation in adult asthmatics.
MedLine Citation:
PMID:  15046377     Owner:  NLM     Status:  MEDLINE    
Reversible airflow limitation represents an important parameter for the diagnosis of bronchial asthma. The aim of this study was to design a simple and useful test for the detection of reversible airflow limitation. The subjects were 29 patients with asthma and forced expiratory volume in 1 second (FEV1) < 80% predicted. Following baseline spirometry, subjects inhaled 1.5 mg of salbutamol by a nebulizer and then spirometry was performed 20 min later. The procedure was repeated three times. Subsequently, 13 patients received 30 mg of predonisolone orally once daily for 1 week. Spirometry was performed before and after the oral predonisolone therapy, and results were compared with those of salbutamol inhalation test. The mean increase in FEV1 over the baseline was 18.3% after the first salbutamol inhalation, 26.4% after the second inhalation, and 30.2% after the third inhalation. The increases in FEV1 were significant after each inhalation. The mean increases in the maximum expiratory flow rate at 50% (V50) and that at 25% (V25), measured from the flow volume loop, were 53.5% and 46.9% after the first inhalation, but there were no significant changes by repeated inhalations. A significant reversal of airflow limitation was demonstrated in 18 subjects after the first inhalation, 22 subjects after the second inhalation, and 27 subjects after the third inhalation. Improvement in FEV1 after oral predonisolone was equivalent to that after the third inhalation of salbutamol. A test composed of three 20-min interspaced salbutamol inhalations is useful for the diagnosis of asthma by demonstrating the presence of reversible airflow limitation.
Shinya Tomari; Hiroto Matsuse; Ikuko Machida; Yuki Kondo; Tetsuya Kawano; Yasushi Obase; Chizu Fukushima; Terufumi Shimoda; Shigeru Kohno
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  41     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-29     Completed Date:  2004-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-8     Citation Subset:  IM    
Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
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MeSH Terms
Administration, Inhalation
Administration, Oral
Airway Obstruction / diagnosis,  drug therapy,  etiology
Albuterol / administration & dosage,  diagnostic use*
Anti-Inflammatory Agents / administration & dosage,  therapeutic use
Asthma / diagnosis,  drug therapy,  physiopathology*
Bronchodilator Agents / administration & dosage,  diagnostic use*
Forced Expiratory Volume*
Middle Aged
Prednisolone / administration & dosage,  therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Bronchodilator Agents; 18559-94-9/Albuterol; 50-24-8/Prednisolone

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