| Threats to validity in randomized clinical trials. | |
MedLine Citation:
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PMID: 10686575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purposes of this article are to present an overview of randomized clinical trials (RCTs) and describe some of the methodological problems inherent in using RCTs in nursing research. Many nursing intervention studies are fraught with problems that defy the stringent control criteria required for RCTs, leading to biased estimates of intervention efficacy. Five threats to validity in RCTs are presented, including problems related to (a) differential dropout, (b) random assignment, (c) identifying and maintaining an adequate control condition, (d) nonadherence to research protocols, and (e) assessment of clinically meaningful change. Three strategies are recommended for addressing some of the problems posed by RCTs and improving inference. |
Authors:
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L Fogg; D Gross |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Research in nursing & health Volume: 23 ISSN: 0160-6891 ISO Abbreviation: Res Nurs Health Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-03-22 Completed Date: 2000-03-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806136 Medline TA: Res Nurs Health Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 79-87 Citation Subset: IM; N |
Copyright Information:
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Copyright 2000 John Wiley & Sons, Inc. 23:79-87, 2000 |
Affiliation:
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Department of Psychology and Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Nursing Research
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methods* Clinical Protocols Guideline Adherence Humans Patient Dropouts Random Allocation Randomized Controlled Trials as Topic / methods* Reproducibility of Results Research Design |
| Grant Support | |
ID/Acronym/Agency:
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R01 NRO4085/NR/NINR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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