Document Detail

The thoracoscopic talc pleurodesis with intraoperative pleural biopsy - a retrospective analysis in patients with malignant pleural effusion
MedLine Citation:
PMID:  20029741     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The thoracoscopic pleurodesis with talc is an established therapy in case of malignant pleural effusion. With the instillation of talc a -localised inflammation is induced. However, some-times it turns into a severe systemic reaction. In this study of the postoperative course, the -question is examined whether a pleural biopsy is an additional risk factor for morbidity and mortality after talc pleurodesis. PATIENTS AND METHODS: Between January 2002 and December 2004, 77 patients with a malignant pleural effusion were enrolled in this retrospective trial. All patients received a thoracoscopic talc pleurodesis. The patients were divided retrospectively into two groups: 50 patients with an intra-operative pleural biopsy, 27 patients without a biopsy were the control group. C-reactive protein (CrP), leukocytes, and creatinine were -analysed. RESULTS: In both groups, CrP and leukocytes increased postoperatively with a peak on day 2 or 3. In general, the analysed data for creatinine -showed in the median standard values but with a high range up to at most 317 micromol / L on the 2 (nd) postoperative day, also in both groups. At no time was any significant difference in laboratory values seen among the two groups. Concerning morbidity and mortality also no significant difference could be determined. CONCLUSIONS: There were no significant differences for the examined laboratory values or for the morbidity / mortality between the two groups. That is why a disadvantage for patients with an intraoperative pleural biopsy is not to be expected.
B Hoksch; N Seidel; M Beshay; R A Schmid
Publication Detail:
Type:  Comparative Study; English Abstract; Journal Article     Date:  2009-12-22
Journal Detail:
Title:  Zentralblatt f?r Chirurgie     Volume:  135     ISSN:  1438-9592     ISO Abbreviation:  Zentralbl Chir     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413645     Medline TA:  Zentralbl Chir     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  54-8     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag Stuttgart, New York.
General Thoracic Surgery, University Hospital Bern, Inselspital, 3010 Bern, Switzerland.
Vernacular Title:
Die thorakoskopische Talkumpleurodese mit Pleurabiopsie - eine retrospektive Analyse bei Patienten mit malignem Pleuraerguss.
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MeSH Terms
Aged, 80 and over
Breast Neoplasms / pathology,  therapy
C-Reactive Protein / metabolism*
Carcinoma, Non-Small-Cell Lung / pathology,  therapy
Chest Tubes
Creatinine / blood*
Leukocyte Count*
Lung Neoplasms / pathology,  therapy
Middle Aged
Pleura / immunology,  pathology*
Pleural Effusion, Malignant / therapy*
Pleurodesis / methods*
Postoperative Care
Postoperative Complications / immunology*
Risk Factors
Systemic Inflammatory Response Syndrome / immunology*
Talc / administration & dosage*
Thoracoscopy / methods*
Reg. No./Substance:
14807-96-6/Talc; 60-27-5/Creatinine; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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