Document Detail


Thoracoabdominal asynchrony in infants with airflow obstruction.
MedLine Citation:
PMID:  2137313     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thoracoabdominal asynchrony (TAA) has long been thought clinically useful in the assessment of airflow obstruction (AO) in infants. To test the hypothesis that the measurement of TAA is useful in the assessment of lung mechanics in infants with AO, we have used respiratory inductive plethysmography (RIP) to quantity TAA. We compared changes in TAA to changes in lung mechanics before and after aerosolized bronchodilator (BD) administration in 13 infants. Abdominal wall (AB) and rib cage (RC) motion were displayed on an X-Y recorder in a Lissajous figure. Asynchrony between RC and AB motion was quantified by comparing the width m of the Lissajous figure (difference between AB inspiratory and expiratory positions) at mid-RC excursion with the total AB excursion at its extremes (s). Phase angle phi ws computed as sin phi = m/s (or phi = 180 degrees - mu, where sin mu = m/s for phase angles greater than 90 degrees) and was taken as a measure of TAA. Lung resistance RL and elastance EL were calculated from esophageal pressure (Pes), mouth pressure, tidal volume, and tidal flow. All infants displayed TAA at baseline. After BD administration, TAA decreased in those infants in whom RL decreased. The percentage decrease in the phase angle from baseline after BD administration was significantly correlated with the decrease in peak-to-peak Pes (delta Pes) and the percentage decrease in RL and EL. We conclude that AO in infants leads to TAA through altered pleural pressure swings acting on the compliant chest wall. Changes in lung mechanics induced by bronchodilators are reflected in changes in TAA.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
J L Allen; M R Wolfson; K McDowell; T H Shaffer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  141     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-15     Completed Date:  1990-03-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  337-42     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Temple University School of Medicine, Philadelphia, PA.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Muscles / drug effects,  physiopathology*
Aerosols
Airway Obstruction / diagnosis,  drug therapy,  physiopathology*
Bronchiolitis, Viral / drug therapy,  physiopathology
Bronchodilator Agents / therapeutic use
Bronchopulmonary Dysplasia / drug therapy,  physiopathology
Humans
Infant
Infant, Newborn
Plethysmography / methods
Respiratory Mechanics / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
HL 1R29 41132-01/HL/NHLBI NIH HHS; HL 32301/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Aerosols; 0/Bronchodilator Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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