Document Detail


Thoraco-abdominal high-pitch dual-source CT angiography: Experimental evaluation of injection protocols with an anatomical human vascular phantom.
MedLine Citation:
PMID:  22226854     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To experimentally evaluate three different contrast injection protocols at thoraco-abdominal high-pitch dual-source computed tomography angiography (CTA), with regard to level and homogeneity of vascular enhancement at different cardiac outputs. MATERIALS AND METHODS: A uniphasic, a biphasic as well as an individually tailored contrast protocol were tested using a human vascular phantom. Each protocol was scanned at 5 different cardiac outputs (3-5L/min, steps of 0.5L/min) using an extracorporeal cardiac pump. Vascular enhancement of the thoraco-abdominal aorta was measured every 5cm. Overall mean enhancement of each protocol and mean enhancement for each cardiac output within each protocol were calculated. Enhancement homogeneity along the z-axis was evaluated for each cardiac output and protocol. RESULTS: Overall mean enhancement was significantly higher in the uniphasic than in the other two protocols (all p<.05), whereas the difference between the biphasic and tailored protocol was not significant (p=.76). Mean enhancement among each of the 5 cardiac outputs within each protocol was significantly different (all p<.05). Only within the tailored protocol mean enhancement differed not significantly at cardiac outputs of 3.5L/min vs. 5L/min (484±25HU vs. 476±19HU, p=.14) and 4 vs. 5L/min (443±49HU vs. 476±19HU, p=.05). Both, uniphasic and tailored protocol yielded homogenous enhancement at all cardiac outputs, whereas the biphasic protocol failed to achieve homogenous enhancement. CONCLUSION: This phantom study suggests that diagnostic and homogenous enhancement at thoraco-abdominal high-pitch dual-source CTA is feasible with either a uniphasic or an individually tailored contrast protocol.
Authors:
Gilbert D Puippe; Anna Winklehner; Peter Hasenclever; André Plass; Thomas Frauenfelder; Stephan Baumueller
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-6
Journal Detail:
Title:  European journal of radiology     Volume:  -     ISSN:  1872-7727     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Institute for Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland Raemistrasse 100, CH-8091 Zurich, Switzerland.
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