Document Detail


Thoracic radiotherapy in patients with lymphoma and restenosis after coronary stent placement.
MedLine Citation:
PMID:  17722039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of this study was to assess the incidence of restenosis after coronary stenting in patients with lymphoma treated with thoracic radiation. BACKGROUND: Patients with Hodgkin lymphoma treated with thoracic radiation have an increased incidence of coronary artery disease (CAD). The incidence of restenosis after percutaneous coronary interventions is completely unknown. METHODS: This study included 12,626 consecutive patients with CAD treated with coronary stenting during a 10-year period. Within this cohort, three subgroups of patients were assessed: patients with lymphoma and previous thoracic radiation (15 patients), patients with lymphoma without thoracic radiation (7 patients) and patients without lymphoma or previous thoracic radiation (control group; 12,604 patients). Coronary stenting was performed after a median [25th; 75th percentiles] of 8 years [4; 17] after thoracic radiation. The primary end point of the study was restenosis at 6-month coronary angiography. RESULTS: Six-month coronary angiography was performed in 14 patients (93%) in the group with lymphoma and radiation, 6 patients (86%) in the group with lymphoma without radiation and 10,032 patients (80%) in the control group (P = 0.38). Angiographic restenosis was found in 12 patients (85.7%) in the group with lymphoma and radiation, 1 patient (16.7%) in the group with lymphoma without radiation and 2,555 patients (25.5%) in the control group (P < 0.001). Multiple logistic regression identified thoracic radiation as an independent predictor of coronary restenosis (odds ratio 21.7, 95% confidence interval, 4.7-100.9, P < 0.001). CONCLUSIONS: Patients with lymphoma treated with thoracic radiation have an increased risk of restenosis after coronary artery stenting.
Authors:
Kathrin Schömig; Gjin Ndrepepa; Julinda Mehilli; Jürgen Pache; Adnan Kastrati; Albert Schömig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  70     ISSN:  1522-1946     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-03     Completed Date:  2007-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  359-65     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Affiliation:
Deutsches Herzzentrum, Technische Universität Munich, Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Vessel Prosthesis Implantation / instrumentation*
Coronary Angiography
Coronary Disease / etiology,  radiography,  surgery
Coronary Restenosis / epidemiology,  etiology*,  radiography
Coronary Vessels / radiation effects*
Female
Follow-Up Studies
Germany / epidemiology
Hodgkin Disease / complications,  radiotherapy*
Humans
Incidence
Lymphoma, Non-Hodgkin / complications,  radiotherapy*
Male
Middle Aged
Myocardial Revascularization / methods*
Prospective Studies
Risk Factors
Stents*
Comments/Corrections
Comment In:
Catheter Cardiovasc Interv. 2007 Sep1;70(3):366-7   [PMID:  17722040 ]

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