Document Detail

Thoracic manifestation of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-related disease. CT findings in 51 patients.
MedLine Citation:
PMID:  15480049     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the pulmonary CT findings of patients with serum evidence of the myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA). METHODS: The pulmonary CT scans of 62 patients with serum evidence of MPO-ANCA (51 with microscopic polyangiitis, 11 with Churg-Strauss syndrome) were retrospectively assessed with regard to parenchymal, pleural, and mediastinal abnormalities. RESULTS: On the CT scans, abnormal findings were seen in 51 of the patients (82%, n = 62). Of the patients, the CT findings consisted of ground-glass attenuation in 48 of the patients (94%, n = 51), consolidation in 40 (78%), and thickening of bronchovascular bundles in 26 (51%). Pathologically, these findings corresponded to alveolar hemorrhages, interstitial chronic inflammation in the alveolar septa, vasculitis, or fibrosis. These abnormalities were predominantly seen in peripheral lung parenchyma (n = 37). CONCLUSION: The CT findings in patients with MPO-ANCA consisted mainly of ground-glass attenuation and consolidation in the peripheral lung. These findings, although nonspecific, are considered as pulmonary involvement in patients with MPO-ANCA.
Yumiko Ando; Fumito Okada; Shunro Matsumoto; Hiromu Mori
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of computer assisted tomography     Volume:  28     ISSN:  0363-8715     ISO Abbreviation:  J Comput Assist Tomogr     Publication Date:    2004 Sep-Oct
Date Detail:
Created Date:  2004-10-14     Completed Date:  2006-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7703942     Medline TA:  J Comput Assist Tomogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  710-6     Citation Subset:  IM    
Department of Academic Radiology, Oita University Faculty of Medicine, Idaigaoka, Hasama-machi, Oita 879-5593, Japan.
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MeSH Terms
Antibodies, Antineutrophil Cytoplasmic / blood*
Follow-Up Studies
Middle Aged
Peroxidase / blood*
Retrospective Studies
Thoracic Diseases / blood*,  enzymology,  immunology,  radiography*
Tomography, X-Ray Computed*
Tumor Markers, Biological / blood*
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic; 0/Tumor Markers, Biological; EC

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