| Thoracic epidural clonidine attenuates haemodynamic responses induced by endobronchial intubation. | |
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MedLine Citation:
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PMID: 17294988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Laryngoscopy and endobronchial intubation usually cause transient hypertension and tachycardia. We investigated whether thoracic epidurally injected 3 microg/kg clonidine attenuates cardiovascular responses to intubation compared with 2 microg/kg fentanyl and 1 mg/kg lidocaine. Epidural catheterization was performed at the T6-T7 or T7-T8 intervertebral space, and saline or clonidine in saline was injected 20 min before anaesthetic induction. Anaesthesia was induced using 5 mg/kg thiopental sodium and 0.1 mg/kg vecuronium. Laryngoscopy and endobronchial intubation were performed 2 min later. Mean blood pressure and heart rate were measured throughout anaesthetic induction. In the control group and the fentanyl group, mean blood pressure and heart rate 3 min after endobronchial intubation were elevated significantly compared with baseline. In the clonidine group, however, mean blood pressure and heart rate did not increase compared with baseline. The control group had higher mean blood pressure and heart rate than the clonidine group 3 min after endobronchial intubation. Thoracic epidural clonidine may attenuate the haemodynamic response to endobronchial intubation. |
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Authors:
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S U Choi; C H Lim; H W Lee; S H Lee; K Sun; H J Lim; S M Yoon; S H Chang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of international medical research Volume: 34 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2006 Nov-Dec |
Date Detail:
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Created Date: 2007-02-13 Completed Date: 2007-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
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Languages: eng Pagination: 565-72 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology and Pain Medicine, Korea University Medical Center, Sungbuk-gu, Seoul, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bronchi Clonidine / administration & dosage, pharmacology* Female Humans Hypertension / prevention & control* Injections, Epidural Intubation, Intratracheal Male Prospective Studies Tachycardia / prevention & control* |
| Chemical | |
Reg. No./Substance:
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4205-90-7/Clonidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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