Document Detail

Thoracic electrical bioimpedance measurement of cardiac output and cardiovascular responses to the induction of anaesthesia and to laryngoscopy and intubation.
MedLine Citation:
PMID:  1415969     Owner:  NLM     Status:  MEDLINE    
Noninvasive methods of determining cardiac output (by thoracic electrical bioimpedance) and arterial pressure (by intermittent oscillometry) were used to record minute-by-minute changes in heart rate, mean arterial pressure, stroke volume, cardiac output and systemic vascular resistance following induction of general anaesthesia and laryngoscopy and intubation in 60 healthy female patients who were either unpremedicated, or premedicated with temazepam or papaveretum-hyoscine. Anaesthesia was induced with a sleep dose (3-5 of thiopentone and maintained with 70% nitrous oxide in oxygen with 0.5-1% enflurane. Tracheal intubation was facilitated by administration of vecuronium 0.1 Mean arterial pressure and cardiac output decreased maximally 5 min after induction in all premedication groups by mean estimates of 21-25% and 14-22% respectively. Heart rate increased initially one minute after induction, but decreased to less than the baseline value 5 min after induction. Systemic vascular resistance was unchanged. The stimulus of laryngoscopy and tracheal intubation was accompanied by a significant pressor response and tachycardia one minute after intubation (with mean increases in mean arterial pressure and heart rate of 29-34% and 22-33% respectively). The increase in mean arterial pressure was secondary to an increase in systemic vascular resistance (36-57%), and was accompanied by a decrease in stroke volume (-25 to -31%). These changes were significant in all three groups. Cardiac output decreased only in unpremedicated patients. There were wide variations in the different haemodynamic indices.(ABSTRACT TRUNCATED AT 250 WORDS)
D J Sanders; C F Jewkes; J W Sear; F Verhoeff; P Foëx
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia     Volume:  47     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-16     Completed Date:  1992-11-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  736-40     Citation Subset:  AIM; IM    
Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington.
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MeSH Terms
Anesthesia, Inhalation*
Anesthesia, Intravenous*
Cardiac Output / drug effects,  physiology
Cardiography, Impedance*
Hemodynamics / drug effects,  physiology*
Intubation, Intratracheal*
Middle Aged
Preanesthetic Medication
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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