Document Detail

Thoracic duct lymph flow in pregnant sheep and response to blood volume expansion.
MedLine Citation:
PMID:  3717382     Owner:  NLM     Status:  MEDLINE    
Left thoracic duct lymph flow rate averaged 0.077 +/- 0.003 (SD) and 0.078 +/- 0.003 ml X min-1 X kg-1 in near-term pregnant and nonpregnant sheep (P greater than 0.5). Lymph and plasma protein concentrations were unaltered in the pregnant compared with the nonpregnant animals. The thoracic duct lymph flow responses to three serial intravenous infusions of lactated Ringer solution were essentially the same in the pregnant and nonpregnant animals. Blood volume and vascular pressure changes during and after volume loading were essentially the same in both groups. In addition, terbutaline administration after volume loading caused no change in thoracic duct lymph flow rates. Thus the present study suggests that basal lymph flow rates, lymphatic function, and vascular as well as interstitial compliances are largely unaltered late in pregnancy in the sheep. In addition, beta-mimetic stimulation with terbutaline does not appear to suppress lymph flow rate.
G Valenzuela; L L Woods; R A Brace
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  250     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-24     Completed Date:  1986-07-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1095-8     Citation Subset:  IM    
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MeSH Terms
Blood Proteins / metabolism
Blood Volume / drug effects
Extracellular Space / physiology
Isotonic Solutions / pharmacology
Lymph / drug effects,  metabolism,  physiology*
Osmolar Concentration
Plasma Substitutes / pharmacology*
Proteins / metabolism
Terbutaline / pharmacology
Thoracic Duct / physiology*
Vascular Resistance
Reg. No./Substance:
0/Blood Proteins; 0/Isotonic Solutions; 0/Plasma Substitutes; 0/Proteins; 23031-25-6/Terbutaline; 8022-63-7/Ringer's lactate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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