| Thoracic duct lymph flow: a comparative study in newborn and adult sheep. | |
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MedLine Citation:
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PMID: 3701005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To understand better developmental changes in body fluid dynamics, we studied thoracic duct lymph flow in 9 newborn and 5 adult sheep. The experiments were carried out under general anaesthesia following bilateral ligation of the renal vessels and ureters. After a 30 min control period, we administered three successive 5-min intravenous infusions of isotonic saline equivalent to 2% of body weight each, at 30-min intervals. The average basal lymph flow rate was 0.157 +/- 0.033 (SEM) ml.min-1.kg-1 and 0.046 +/- 0.018 ml.min-1.kg-1 in newborns and adults respectively (p less than 0.05). Fluid overloading resulted into similar intravascular retentions at the end of each 30-min period in both groups although the increase in lymph flow was repeatedly more than three times higher in the newborns. The more pronounced lymph flow response in the newborns could not be accounted for only on the basis of a difference in capillary filtration. We speculate that interstitial forces and/or the lymphatic pumping activity play a greater role in facilitating fluid movements in the newborn lamb than in the adult ewe. Overall, the higher capacity of the newborn to eliminate excess interstitial fluid constitutes a significant factor in the body's defense against oedema. |
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Authors:
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B Harake; G G Power |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of developmental physiology Volume: 8 ISSN: 0141-9846 ISO Abbreviation: J. Dev. Physiol. Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-06-09 Completed Date: 1986-06-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7910737 Medline TA: J Dev Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 87-95 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Animals, Newborn Biomechanics Blood Volume Capillary Permeability Extracellular Space / physiology Female Lymph / physiology* Male Sheep / physiology* Thoracic Duct / physiology* |
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