| Thoracic computed tomography findings in dogs experimentally infected with angiostrongylus vasorum. | |
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MedLine Citation:
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PMID: 21554477 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To characterize the computed tomography (CT) features of thoracic lesions caused by infection with Angiostrongylus vasorum, pre- and postcontrast CT was performed in six experimentally infected Beagles 13 weeks postinoculation and in four of these 9 weeks postchemotherapy. Findings were compared with survey radiographs and necropsy findings. A multicentric bronchoalveolar pattern more pronounced at the lung periphery was present radiographically. On CT, the predominant abnormality underlying this alveolar pattern was multiple large nodules merging to areas of consolidation, and containing air bronchograms of varying extent. These nodular changes corresponded to histopathologic granulomata, consisting mainly of macrophages, multinucleated giant cells, and lymphocytes that had accumulated around larvae and eggs. Morphologically, no bronchial changes were observed on CT or histologically. Quantitatively, however, on CT there was evidence of bronchial thickening at 13 weeks postinoculation and mild very peripheral bronchiectasia 9 weeks postchemotherapy. Regional lymph nodes were enlarged after infection, and smaller after treatment. On postcontrast CT, several suspicious intraluminal filling defects suggestive of thrombosis were found; however, the tortuosity of some pulmonary arteries seen radiographically was not present in CT images. After treatment, the consolidations and large nodules had almost completely disappeared. A remaining radiographic interstitial pattern was characterized on CT as ground-glass opacifications, subpleural interstitial thickening, subpleural lines, and interface signs. These interstitial changes reflected fibrosis as documented histopathologically. CT allowed very detailed and accurate characterization of pulmonary parenchymal lesions, bronchi, and lymphnodes and closely reflected histopathological changes. |
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Authors:
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Matthias Dennler; Mariano Makara; Asia Kranjc; Manuela Schnyder; Pete Ossent; Peter Deplazes; Stefanie Ohlerth; Tony M Glaus |
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Publication Detail:
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Type: Journal Article Date: 2010-12-28 |
Journal Detail:
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Title: Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association Volume: 52 ISSN: 1058-8183 ISO Abbreviation: Vet Radiol Ultrasound Publication Date: 2011 May-Jun |
Date Detail:
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Created Date: 2011-05-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9209635 Medline TA: Vet Radiol Ultrasound Country: United States |
Other Details:
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Languages: eng Pagination: 289-94 Citation Subset: IM |
Copyright Information:
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© 2010 Veterinary Radiology & Ultrasound. |
Affiliation:
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Section of Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland Division of Cardiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland Institute of Parasitology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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