Document Detail

Thoracic aorta atherosclerosis burden index predicts coronary artery disease in patients undergoing transesophageal echocardiography.
MedLine Citation:
PMID:  17524407     Owner:  NLM     Status:  MEDLINE    
AIMS: The severity of thoracic aortic atherosclerosis (TAA) is associated with the extent of coronary artery disease (CAD). The aim of this study is to quantitative this relationship by developing a novel atherosclerotic index. METHODS AND RESULTS: Two hundred and forty six consecutive patients underwent transesophageal echocardiography (TEE) and coronary angiography. A grading system was used to define the extent of TAA for individual segment of the thoracic aorta. TAA burden index (TAABI) was defined as the sum of the grading for each segment. Of the derived values TAABI had the greatest specificity and sensitivity in predicting CAD. A TAABI of greater than 6 was associated with 16-fold increase in the probability of CAD with a specificity of 88% and a sensitivity of 81%. The positive predictive value was 77% and the negative predictive value 90%. CONCLUSION: A TAABI value of greater than 6 accurately predicts the presence of CAD. Patients with no or mild TAA are at low risk of having angiographically significant CAD.
Alexandra Frogoudaki; John Barbetseas; Constadina Aggeli; Demosthenes Panagiotakos; Spyros Lambrou; Christos Pitsavos; Christodoulos Stefanadis
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2007-05-23
Journal Detail:
Title:  Atherosclerosis     Volume:  197     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  232-6     Citation Subset:  IM    
Thriasion General Hospital, Magoula, Greece.
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MeSH Terms
Aorta, Thoracic / ultrasonography*
Atherosclerosis / epidemiology,  ultrasonography*
Coronary Angiography
Coronary Artery Disease / epidemiology,  radiography,  ultrasonography*
Echocardiography, Transesophageal*
Middle Aged
Predictive Value of Tests
Risk Factors
Sensitivity and Specificity
Severity of Illness Index*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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