| Thoracic epidural anesthesia attenuates endotoxin-induced impairment of gastrointestinal organ perfusion. | |
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MedLine Citation:
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PMID: 20526186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Systemic inflammation can be associated with a redistribution of organ blood flow and a decrease in gastrointestinal perfusion. Regional sympathetic blockade by means of thoracic epidural anesthesia (TEA) has been shown to improve intestinal microcirculation during systemic inflammation. This study tests the hypothesis that during systemic inflammation, TEA attenuates the impairment of gastrointestinal organ perfusion without compromising blood flow to vital organs. METHODS: Eighteen rats were anesthetized, hemodynamically monitored, and mechanically ventilated with room air. By using fluorescent microspheres, organ perfusion was quantified at baseline, 30 min after the start of epidural infusion of either 2% lidocaine (TEA) or normal saline (control), and after 60 and 120 min of intravenous Escherichia coli lipopolysaccharide infusion in TEA and control animals. RESULTS: Blood pressure initially was lower in TEA animals, but it was comparable to controls during endotoxemia. Gastrointestinal organ perfusion significantly decreased after 120 min of endotoxemia in the controls but not in the TEA animals (-23 +/- 27% vs. -6 +/- 26%, mean +/- SD, P < 0.05). Perfusion of the vital organs such as the heart, brain, liver, and kidneys was comparable between controls and TEA after 120 min of endotoxemia. CONCLUSIONS: TEA attenuates the impairment of gastrointestinal organ perfusion during endotoxemia. Hence, the protective effects of TEA on intestinal microcirculation during endotoxemia may be due to a higher total organ blood flow compared with endotoxemic control animals. Furthermore, in the course of endotoxemia, TEA provides hemodynamic stability and does not compromise blood flow to vital organs. |
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Authors:
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Jörn Schäper; Raees Ahmed; Frank Holger Perschel; Michael Schäfer; Helmut Habazettl; Martin Welte |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesiology Volume: 113 ISSN: 1528-1175 ISO Abbreviation: Anesthesiology Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-25 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 126-33 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany. joern.schaeper@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Epidural
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methods* Anesthetics, Local / blood, pharmacology* Animals Catecholamines / blood Disease Models, Animal Endotoxemia / chemically induced, physiopathology* Endotoxins Gastrointestinal Tract / blood supply*, drug effects* Lidocaine / blood, pharmacology* Male Microcirculation / drug effects Microspheres Rats Rats, Sprague-Dawley Sodium Chloride / administration & dosage Thoracic Vertebrae |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Catecholamines; 0/Endotoxins; 137-58-6/Lidocaine; 67924-63-4/endotoxin, Escherichia coli; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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