Document Detail


Third form of the precursor to the major merozoite surface antigens of Plasmodium falciparum.
MedLine Citation:
PMID:  3043189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The precursor to the major merozoite surface antigens of Plasmodium falciparum appears to be encoded by two distinctly different (dimorphic) alleles able to undergo limited recombination. We analyzed 18 previously uncharacterized P. falciparum isolates to test the dimorphic model. All but one, a Thailand isolate, conformed to the dimorphic model, and this isolate conformed to the dimorphic model in all but variable block 2. Sequence analysis revealed that block 2 of isolate CSL2 was a third form. Hence, the dimorphic model is not strictly correct. Recombination between alleles was found only within two conserved blocks near the 5' end of the gene.
Authors:
M G Peterson; R L Coppel; M B Moloney; D J Kemp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biology     Volume:  8     ISSN:  0270-7306     ISO Abbreviation:  Mol. Cell. Biol.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-09-16     Completed Date:  1988-09-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8109087     Medline TA:  Mol Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2664-7     Citation Subset:  IM    
Affiliation:
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Animals
Antigens, Protozoan / genetics*
Base Sequence
DNA / metabolism
Molecular Sequence Data
Nucleic Acid Hybridization
Plasmodium falciparum / genetics*,  immunology
Protein Precursors / genetics*
Chemical
Reg. No./Substance:
0/Antigens, Protozoan; 0/Protein Precursors; 9007-49-2/DNA
Comments/Corrections

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