| Third Trimester Fetal Heart Rate and Doppler Middle Cerebral Artery Blood Flow Velocity Characteristics during prenatal Selective Serotonin Reuptake Inhibitor (SSRI) exposure. | |
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MedLine Citation:
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PMID: 21436759 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Prenatal selective serotonin reuptake inhibitor (SSRI) exposure increases the risk for adverse neonatal behavioral outcomes; though it is unknown if altered brain function is present prior to birth. We investigated fetal vascular and heart rate changes at 36 weeks gestation in SSRI-treated women with mood disorders (n=29) (exposed, EXP) and controls (n=45) (non-exposed, NEXP). Fetal middle cerebral artery (MCA) flow parameters and heart rate characteristics were obtained during pre SSRI dose morning and post dose afternoon sessions. Maternal mood and cord Hb and hematocrit were measured. Basal fetal heart rate (fHR) did not differ between groups or across the day. fHR short and long term variations, accelerations and duration of high variability episodes remained lower and did not change across the day in EXP, while all increased significantly in NEXP. In both groups MCA flow velocity and volume flow increased significantly across the day. EXP MCA pulstatility index (PI) was significantly lower, as was MCA cross-sectional area. EXP cord Hb and hematocrit were significantly elevated. Prenatal SSRI exposure reduced fetal MCA flow resistance and fHR variability, before and after an SSRI dose, controlling for maternal mood. These changes and the SSRI-related increased red cell indices suggest possible fetal hypoxia. ABBREVIATIONS:: |
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Authors:
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Dan Rurak; Ken Lim; Ari Sanders; Ursula Brain; Wayne Riggs; Tim F Oberlander |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-23 |
Journal Detail:
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Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departments of Obstetrics & Gynecology [D.R., K.L.] and Pediatrics [U.B., T.F.O], Faculty of Pharmaceutical Sciences [W.R.], Child & Family Research Institute [D.R., K.L., A.S., U.B., T.F.O], University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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