Document Detail

Thioxanthines with potent brochodilator and coronary dilator properties.
MedLine Citation:
PMID:  13684289     Owner:  NLM     Status:  MEDLINE    
Some of the pharmacological properties of two new compounds, choline 6-thiotheophyllinate and the choline salt of 3-isobutyl-1-methyl-6-thioxanthine (M&B 5924), are described. Both these 6-thioxanthines are structurally related to theophylline and pharmacologically they are very similar to that compound, the main differences in their actions being essentially quantitative. They were more potent than choline theophyllinate as bronchodilators on the isolated guinea-pig tracheal ring preparation and as coronary dilators on the dog heart-lung preparation. Choline 6-thiotheophyllinate was about as effective as its oxygen analogue in protecting guinea-pigs against the lethal effects of a bronchoconstrictor aerosol; M&B 5924 was more effective in this respect, but the relative bronchodilator activity was much less than on the isolated preparation. Both thioxanthines were less potent than choline theophyllinate as diuretics. One outstanding qualitative difference in their properties was in their effect on the voluntary motor activity of mice; choline theophyllinate in low doses was stimulant whereas the thioxanthines were either inactive at low doses or sedative at higher doses. In dogs, on the other hand, there were indications that M&B 5924 had a stimulant action.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology and chemotherapy     Volume:  16     ISSN:  0366-0826     ISO Abbreviation:  Br J Pharmacol Chemother     Publication Date:  1961 Feb 
Date Detail:
Created Date:  1961-12-01     Completed Date:  1998-11-01     Revised Date:  2010-09-20    
Medline Journal Info:
Nlm Unique ID:  0154627     Medline TA:  Br J Pharmacol Chemother     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  59-76     Citation Subset:  OM    
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MeSH Terms
Bronchi / pharmacology*
Coronary Vessels / pharmacology*
Theophylline / analogs & derivatives*
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Vasodilator Agents; 58-55-9/Theophylline

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