| Thioredoxin suppresses airway inflammation independently of systemic Th1/Th2 immune modulation. | |
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MedLine Citation:
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PMID: 20017193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidative stress plays an important role in the pathogenesis of asthma via the upregulation of local inflammatory mediators and/or promoting Th2-skewing during Ag sensitization. Thioredoxin (TRX), a 12 kDa redox-active protein with antioxidative property, has been recently shown to play a protective role in various inflammatory diseases. Using a mouse model of asthma, we show here that IL-13 and eotaxin production are decreased in TRX-Tg mice leading to reduced eosinophils recruitment and mucus metaplasia. The reduction in airway inflammation occurs without the attenuation of systemic Th2 immunity in that comparable levels of Th2-type cytokines and Ig were detected in LN and serum, respectively, from TRX-Tg and WT mice. Likewise, CD4(+) T cells from both strains of mice developed similar Th1 and Th2 responses in vitro. Asthmatic lungs of TRX-Tg and WT mice contained similar amounts of GATA-3(+) and Foxp3(+) T cells. Finally, production of MIF, an upstream modulator of airway inflammation, was significantly reduced in the lungs of TRX-Tg mice. Our data suggest that TRX suppresses airway inflammation by inhibiting MIF production thereby limiting the downstream recruitment of eosinophils to the lung independently of modulating systemic Th1/Th2 immunity. |
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Authors:
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Mie Torii; Linan Wang; Ning Ma; Kanako Saito; Tomohide Hori; Maremi Sato-Ueshima; Yoshikazu Koyama; Hiroyoshi Nishikawa; Naoyuki Katayama; Akira Mizoguchi; Hiroshi Shiku; Junji Yodoi; Kagemasa Kuribayashi; Takuma Kato |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of immunology Volume: 40 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-11 Completed Date: 2010-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 787-96 Citation Subset: IM |
Affiliation:
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Department of Cellular and Molecular Immunology, Mie University Graduate School of Medicine, Tsu, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asthma / immunology*, metabolism Cell Differentiation / immunology Chemotaxis, Leukocyte / immunology Enzyme-Linked Immunosorbent Assay Eosinophils / immunology Humans Interleukin-13 / biosynthesis, metabolism Intramolecular Oxidoreductases / immunology Macrophage Migration-Inhibitory Factors / immunology Mice Mice, Transgenic Pneumonia / immunology*, metabolism Reverse Transcriptase Polymerase Chain Reaction Th1 Cells / cytology, immunology* Th2 Cells / cytology, immunology* Thioredoxins / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-13; 0/Macrophage Migration-Inhibitory Factors; 52500-60-4/Thioredoxins; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.2.1/Mif protein, mouse |
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