Document Detail

Thioredoxin-1 is a novel and attractive therapeutic approach for various diseases including cardiovascular disorders.
MedLine Citation:
PMID:  19075641     Owner:  NLM     Status:  MEDLINE    
The regulation of cellular reduction/oxidation (redox) balance is critically determined by several antioxidant systems such as the thioredoxin-1 (Trx-1) which reduces disulfides on targeted proteins. In addition, intracellular Trx-1 exerts most of its antioxidant properties through scavenging of reactive oxygen species. Moreover, it acts as a cofactor for several enzymes and plays an important role in the regulation of redox-sensitive transcription factors. Several studies have reported that Trx-1 activity can be modulated by the interaction with vitamin D3-upregulated protein (VDUP-1) (also called Txnip for thioredoxin interacting protein-1 or TBP-2 for Trx-binding protein-2). Trx-1 secretion has been reported to occur in conditions associated with oxidative stress and inflammation. Beneficial effects of elevated plasma Trx-1 levels on various pathologies were reported in mice. In conclusion, oxidative stress is an important actor in various pathologies including cardio- and cerebro-vascular diseases. Therefore, controlling the redox status by increasing the activity of Trx-1 seems to be a novel and an attractive approach.
Ludivine Billiet; Mustapha Rouis
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiovascular & hematological disorders drug targets     Volume:  8     ISSN:  1871-529X     ISO Abbreviation:  -     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101269160     Medline TA:  Cardiovasc Hematol Disord Drug Targets     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  293-6     Citation Subset:  IM    
UMR 7079 / Université Pierre et Marie Curie-Paris 6, Physiologie et Physiopathologie, Bât. A. 5eme étage/Case courrier 256, 7, Quai St-Bernard, 75252 Paris Cedex 5, France.
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MeSH Terms
Antioxidants / metabolism
Cardiovascular Diseases / drug therapy*,  physiopathology
Cerebrovascular Disorders / drug therapy,  physiopathology
Drug Delivery Systems
Oxidative Stress / drug effects*
Reactive Oxygen Species / metabolism
Thioredoxins / drug effects,  metabolism*
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species; 52500-60-4/Thioredoxins

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