| Thiopurine methyltransferase activity in a sample population of black subjects in Florida. | |
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MedLine Citation:
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PMID: 8453854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thiopurine methyltransferase (TPMT), is an enzyme detected in the human red blood cell that catalyzes the S-methylation of thiopurine drugs and is known to exist as a genetic polymorphism in white subjects. Investigations in this laboratory of red blood cell TPMT showed interethnic differences also existed in North American black subjects. A sample group of black subjects in Florida had a mean activity of 8.64 +/- 3.47 U/ml red blood cells and an antimode of 6.5 units, which represented values significantly lower than those obtained for both the mean activity and the antimode in other populations. The findings of this study suggest the possibility that TPMT activity may be under genetic control in North American black subjects and that this ethnic group may be at greater risk of experiencing thiopurine-induced toxicity caused by the lower overall mean activity of the enzyme. |
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Authors:
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C D Jones; C Smart; A Titus; G Blyden; M Dorvil; N Nwadike |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 53 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-04-16 Completed Date: 1993-04-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 348-53 Citation Subset: AIM; IM |
Affiliation:
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Clinical Pharmacology Research Unit, College of Pharmacy and Pharmaceutical Sciences, Florida Agricultural and Mechanical University, Tallahassee 32307. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult African Continental Ancestry Group Aged Analysis of Variance Erythrocytes / enzymology* Female Florida Humans Linear Models Male Methyltransferases / blood* Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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RR03020/RR/NCRR NIH HHS; RR0811/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.1.1.-/Methyltransferases; EC 2.1.1.67/thiopurine methyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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