| Thiopropazate hydrochloride in persistent dyskinesia. | |
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MedLine Citation:
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PMID: 4938244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thiopropazate (Dartalan) was found to be significantly more effective than a placebo in relieving dyskinesia in 23 patients with functional psychosis and persistent dyskinesia associated with prolonged phenothiazine therapy. Each patient whose dyskinesia had persisted unchanged for at least one month after phenothiazine withdrawal received thiopropazate by mouth for three weeks and the placebo for a similar period. Patients were evaluated before the trial, at three weeks, and at six weeks.The drug also improved psychotic behaviour. Possible side effects, which were generally mild, were noted in eight patients, of whom six had Parkinsonism and four drowsiness. None had side effects while on the placebo.The findings indicate that thiopropazate is of value in persistent dyskinesia associated with prolonged phenothiazine intake-a condition hitherto unresponsive to other treatment. Further research is required to determine the long-term effectiveness of the drug. |
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Authors:
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K Singer; M N Cheng |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British medical journal Volume: 4 ISSN: 0007-1447 ISO Abbreviation: Br Med J Publication Date: 1971 Oct |
Date Detail:
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Created Date: 1971-12-07 Completed Date: 1971-12-07 Revised Date: 2010-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0372673 Medline TA: Br Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 22-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Trials as Topic Female Humans Middle Aged Movement Disorders / drug therapy* Parkinson Disease / complications Phenothiazines / therapeutic use* Piperazines / therapeutic use* Psychiatric Status Rating Scales Psychotic Disorders / drug therapy Tranquilizing Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Phenothiazines; 0/Piperazines; 0/Tranquilizing Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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