| Thiopronine-induced herpetiform pemphigus: report of a case studied by immunoelectron microscopy and immunoblot analysis. | |
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MedLine Citation:
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PMID: 8123578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of herpetiform pemphigus induced by thiopronine. Direct immunoelectron microscopy performed on peribullous skin showed IgG deposits predominantly located in the extracellular portion of desmosomes. By immunoblot analysis using bovine tongue extracts as the antigen, the patient's serum recognized a 160-kDa polypeptide which comigrated with desmoglein I. This study underlines the contribution of immunoblot analysis to the diagnosis of atypical cases of pemphigus, and confirms that herpetiform pemphigus may be a clinical variant of pemphigus foliaceus. |
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Authors:
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S Verdier-Sevrain; P Joly; E Thomine; P Belanyi; D Gilbert; F Tron; P Lauret |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The British journal of dermatology Volume: 130 ISSN: 0007-0963 ISO Abbreviation: Br. J. Dermatol. Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-04-14 Completed Date: 1994-04-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 238-40 Citation Subset: IM |
Affiliation:
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Clinique Dermatologique, Hôpital Charles Nicolle, Rouen, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Drug Eruptions / etiology* Humans Immunoblotting Immunoglobulin G / analysis Male Microscopy, Immunoelectron Pemphigus / chemically induced*, immunology Thiopronine / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G; 1953-02-2/Thiopronine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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