Document Detail

Thionamides alter the efficacy of radioiodine treatment in patients with Graves' disease.
MedLine Citation:
PMID:  7631208     Owner:  NLM     Status:  MEDLINE    
Thionamides are often used acutely to control the symptoms of thyrotoxicosis associated with Graves' disease before definitive treatment with radioiodine. Several reports have suggested that pretreatment with thionamides reduces the efficacy of radioiodine therapy in patients with Graves' disease, but other data refute this. This study retrospectively reviewed the records of 95 patients with Graves' disease treated with radioiodine. Pretreatment with thionamides resulted in significantly greater (2 1/2-fold) treatment failure rate than in patients not pretreated with thionamides but given a comparable dose of radioiodine. Higher serum thyroxine concentration at the time of diagnosis was also an independent factor associated with radioiodine treatment failure.
T M Koroscil
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  88     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-05     Completed Date:  1995-09-05     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  831-6     Citation Subset:  AIM; IM    
Endocrinology Service, Wilford Hall USAF Medical Center, Lackland AFB, San Antonio, Tex., USA.
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MeSH Terms
Chi-Square Distribution
Discriminant Analysis
Graves Disease / blood,  complications,  radiotherapy*
Iodine Radioisotopes / therapeutic use*
Methimazole / contraindications*
Middle Aged
Propylthiouracil / contraindications*
Retrospective Studies
Thyrotoxicosis / drug therapy,  etiology
Thyroxine / blood
Treatment Failure
Reg. No./Substance:
0/Iodine Radioisotopes; 51-52-5/Propylthiouracil; 60-56-0/Methimazole; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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