Document Detail


Thiol-yne radical reaction mediated site-specific protein labeling via genetic incorporation of an alkynyl-l-lysine analogue.
MedLine Citation:
PMID:  23450369     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Three alkyne-containing pyrrolysine derivatives were synthesized and genetically encoded into proteins by a mutant PylRS-tRNA pair with high efficiencies. With these alkyne handles, site-specific dual labeling of proteins can be achieved via a bioorthogonal thiol-yne ligation reaction.
Authors:
Yiming Li; Man Pan; Yitong Li; Yichao Huang; Qingxiang Guo
Related Documents :
19357969 - The gene frpb2 of helicobacter pylori encodes an hemoglobin-binding protein involved in...
11460929 - A comprehensive phylogenetic analysis of rieske and rieske-type iron-sulfur proteins.
11941509 - Hybrid cluster proteins (hcps) from desulfovibrio desulfuricans atcc 27774 and desulfov...
20516589 - Structure of stenotrophomonas maltophilia feoa complexed with zinc: a unique prokaryoti...
2012609 - 4-sulphobenzoate 3,4-dioxygenase. purification and properties of a desulphonative two-c...
10769119 - Peroxynitrite-mediated nitration of the stable free radical tyrosine residue of the rib...
11555479 - Functional and expression pattern analysis of chemosensory proteins expressed in antenn...
19330539 - Molecular modification of t4 bacteriophage proteins and its potential application - rev...
18273829 - Genetic evaluation of the hsp70 protein in the japanese quail (coturnix japonica).
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-1
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  -     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
School of Medical Engineering, Hefei University of Technology, Hefei 230009, P. R. China. ymli@hfut.edu.cn.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The hepatitis B virus X protein downregulates NF-?B signaling pathways through decreasing the Notch ...
Next Document:  Misplacement of Central Venous Catheters in the Subclavian Artery: Safe Retrieval with a Percutaneou...