| Thiol-functionalized copolymeric polyesters by lipase-catalyzed esterification and transesterification of 1,12-dodecanedioic acid and its diethyl ester, respectively, with 1-thioglycerol. | |
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MedLine Citation:
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PMID: 20495948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Copolymeric polyoxoesters containing branched-chain methylenethiol functions, i.e., poly(1,12-dodecanedioic acid-co-1-thioglycerol) and poly(diethyl 1,12-dodecanedioate-co-1-thioglycerol), were formed by lipase-catalyzed polyesterification and polytransesterification of 1,12-dodecanedioic acid and diethyl 1,12-dodecanedioate, respectively, with 1-thioglycerol (3-mercaptopropane-1,2-diol) using immobilized lipase B from Candida antarctica (Novozym 435) in vacuo without drying agent in the reaction mixture. After 360-480 h, both polyoxoesters were purified by extraction from the reaction mixtures followed by solvent fractionation. The precipitate of poly(1,12-dodecanedioic acid-co-1-thioglycerol) demonstrated a M(W) of ~170,000 Da, whereas a M(W) of ~7,100 Da only was found for poly(diethyl 1,12-dodecanedioate-co-1-thioglycerol). Both polycondensates were analyzed by GPC/SEC, alkali-catalyzed transmethylation, NMR- and FTIR-spectrometry. |
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Authors:
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Eberhard Fehling; Klaus Bergander; Erika Klein; Nikolaus Weber; Klaus Vosmann |
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Publication Detail:
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Type: Journal Article Date: 2010-05-22 |
Journal Detail:
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Title: Biotechnology letters Volume: 32 ISSN: 1573-6776 ISO Abbreviation: Biotechnol. Lett. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008051 Medline TA: Biotechnol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1463-71 Citation Subset: IM |
Affiliation:
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Max Rubner-Institute, Federal Research Institute for Nutrition and Food, Piusallee 68/76, 48147, Münster, Germany. eberhard.fehling@mri.bund.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Candida
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enzymology* Chromatography, Gel Dicarboxylic Acids / metabolism* Enzymes, Immobilized / metabolism Esterification Gas Chromatography-Mass Spectrometry Glycerol / analogs & derivatives*, metabolism Lipase / metabolism* Magnetic Resonance Spectroscopy Molecular Weight Polyesters / chemistry, isolation & purification, metabolism* Spectroscopy, Fourier Transform Infrared |
| Chemical | |
Reg. No./Substance:
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0/Dicarboxylic Acids; 0/Enzymes, Immobilized; 0/Polyesters; 56-81-5/Glycerol; 693-23-2/dodecanedioic acid; 96-27-5/thioglycerol; EC 3.1.1.-/lipase B, Candida antarctica; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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