Document Detail


Thiocyanate induces cell necrosis and fibrosis in selenium- and iodine-deficient rat thyroids: a potential experimental model for myxedematous endemic cretinism in central Africa.
MedLine Citation:
PMID:  14500569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thyroid destruction leading to endemic myxoedematous cretinism is highly prevalent in central Africa, where iodine (I) and selenium (SE) deficiencies as well as thiocyanate (SCN) overload are combined. All three factors have been studied experimentally in the etiology of the disease, but they have never been studied in combination. In a model using rats, we have previously shown that combining I and SE deficiencies increases the sensitivity of the thyroid to necrosis after iodide overload, an event unlikely to occur in the African situation. To develop a model that would more closely fit with the epidemiological findings, we have determined whether an SCN overload would also result in thyroid necrosis as does the I overload. The combination of the three factors increased by 3.5 times the amount of necrotic cells, from 5.5 +/- 0.3% in the I-SE+ thyroids to 18.9 +/- 1.6% in the I-SE-SCN-overloaded ones. Methimazole administration prevented the SCN-induced necrosis. SE- thyroids evolved to fibrosis, whereas SE+ thyroids did not. TGFbeta was prominent in macrophages present in SE- glands. Thyroid destruction in central Africa might therefore originate from the interaction of three factors: I and SE deficiencies by increasing H(2)O(2) accumulation, SE deficiency by decreasing cell defense and promoting fibrosis, and SCN overload by triggering follicular cell necrosis.
Authors:
Bernard Contempré; Gabriella Morreale de Escobar; Jean-François Denef; Jacques Emile Dumont; Marie-Christine Many
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-09-18
Journal Detail:
Title:  Endocrinology     Volume:  145     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-23     Completed Date:  2004-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  994-1002     Citation Subset:  AIM; IM    
Affiliation:
Institute of Interdisciplinary Research, Free University of Brussels, B-1200 Brussels, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Africa, Central
Animals
Antithyroid Agents / administration & dosage
Congenital Hypothyroidism*
Disease Models, Animal*
Endemic Diseases
Female
Fibrosis
Hydrogen Peroxide / metabolism
Inflammation / pathology
Iodine / deficiency*
Macrophages / chemistry,  pathology
Methimazole / administration & dosage
Myxedema
Necrosis
Perchloric Acid / administration & dosage
Rats
Rats, Wistar
Selenium / deficiency*
Sodium Compounds / administration & dosage
Thiocyanates / toxicity*
Thyroid Gland / pathology*
Transforming Growth Factor beta / analysis
Chemical
Reg. No./Substance:
0/Antithyroid Agents; 0/Sodium Compounds; 0/Thiocyanates; 0/Transforming Growth Factor beta; 302-04-5/thiocyanate; 60-56-0/Methimazole; 7553-56-2/Iodine; 7601-89-0/sodium perchlorate; 7601-90-3/Perchloric Acid; 7722-84-1/Hydrogen Peroxide; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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