Document Detail

Thin-membrane nephropathy--a common cause of glomerular haematuria.
MedLine Citation:
PMID:  2593909     Owner:  NLM     Status:  MEDLINE    
Thin-membrane nephropathy recently has been described as a cause of glomerular haematuria. The prognosis of the condition is unclear but it generally is considered to be benign. In a series of 92 patients with glomerular haematuria, thin-membrane nephropathy was found to be a common cause, occurring in 26 (28%) patients. Sixteen patients were women. The mean age was 42 years. Four patients had a family history of renal disease or haematuria and no patient was deaf. Haematuria had been present from six days to 30 years. Loin pain occurred in 31% of patients. Hypertension was not a feature and mild renal impairment was present in one case only, while a further three cases showed proteinuria at a level of greater than 500 mg of protein per day. Glomerular basement membranes in patients with thin-membrane nephropathy gave a mean (+/- standard deviation) width of 319 + 37 nm which was significantly (P less than 0.002) less than the control value of 394 +/- 61 nm. On the basis of clinical features and serological parameters, thin-membrane nephropathy could not be separated from other renal causes of haematuria but required careful electronmicroscopic examination of renal biopsy material to establish the diagnosis. Limited follow-up has confirmed the good prognosis of the condition.
G J Perry; C R George; M J Field; P V Collett; S Kalowski; R N Wyndham; R C Newland; B P Lin; K L Kneale; J R Lawrence
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Medical journal of Australia     Volume:  151     ISSN:  0025-729X     ISO Abbreviation:  Med. J. Aust.     Publication Date:    1989 Dec 4-18
Date Detail:
Created Date:  1990-01-22     Completed Date:  1990-01-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400714     Medline TA:  Med J Aust     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  638-42     Citation Subset:  IM    
Repatriation General Hospital Concord, NSW.
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MeSH Terms
Basement Membrane / pathology
Hematuria / etiology*
Kidney Diseases / complications*,  pathology
Kidney Glomerulus / ultrastructure
Microscopy, Electron
Middle Aged
Prospective Studies
Retrospective Studies
Comment In:
Med J Aust. 1990 Apr 2;152(7):389   [PMID:  2093827 ]

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