Document Detail


Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales.
MedLine Citation:
PMID:  22566715     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
As part of our ongoing investigation of filamentous fungi for anticancer leads, an active fungal extract was identified from the Mycosynthetix library (MSX 55526; from the Order Sordariales). Bioactivity-directed fractionation yielded the known ergosterol peroxide (2) and 5α,8α-epidioxyergosta-6,9(11),22-trien-3β-ol(3), and a new benzoate trimer, termed thielavin B methyl ester (1). The structure elucidation of 1 was facilitated by the use of HRMS coupled to an APPI (atmospheric pressure photoionization) source. Compound 1 proved to be moderately active against a panel of three cancer cell lines.
Authors:
Sloan Ayers; Brandie M Ehrmann; Audrey F Adcock; David J Kroll; Mansukh C Wani; Cedric J Pearce; Nicholas H Oberlies
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Tetrahedron letters     Volume:  52     ISSN:  0040-4039     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2012-5-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984819R     Medline TA:  Tetrahedron Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  5733-5735     Citation Subset:  -    
Affiliation:
University of North Carolina at Greensboro, Department of Chemistry and Biochemistry, PO Box 26170, Greensboro, NC 27402, United States.
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